PMID: 9427964Jan 15, 1998Paper

Expression of Bax and bcl-2 proteins, regulators of programmed cell death, in human brain tumors

Neurological Research
A HaraH Mori

Abstract

Expression of Bcl-2, a programmed cell death (PCD)-suppressing molecule, and Bax, the Bcl-2 related PCD-accelerating protein was investigated in varied human brain tumors. Thirty-six cases of human brain tumors comprising 4 astrocytomas, 3 anaplastic astrocytomas, 4 glioblastomas multiforme, 5 medulloblastomas, 1 ependymoma, 2 choroid plexus papilloma, 1 ganglioglioma, 1 central neurocytoma, 4 meningotheliomatous meningiomas, 3 transitional meningiomas, 4 fibroblastic meningiomas, 3 acoustic neurinomas and 1 craniopharyngioma were analyzed for the localization of Bax and Bcl-2 proteins. No relationship between the degree of the histological malignancy and the presence of Bax or Bcl-2 proteins was found in varied human brain tumors. However, it is suggested that reduced expression of Bax protein is necessary for the malignant transformation and progression of the brain tumors, since no histologically malignant brain tumors with positive Bax protein were present. Our findings indicate that the expression pattern of Bax and Bcl-2 may reflect histogenetic difference of each type of brain tumors.

Citations

Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·B Yang, R A Prayson
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hidehiro TakeiSuzanne Z Powell
Nov 29, 2002·Brain Tumor Pathology·Cheppail RamachandranSteven J Melnick
Sep 4, 1999·Neuropathology and Applied Neurobiology·D S Tews
Aug 22, 2008·Journal of Neuropathology and Experimental Neurology·Matija SnuderlMark W Kieran
Dec 21, 2010·International Journal of Cancer. Journal International Du Cancer·Tiffany DoucetteGanesh Rao
Sep 16, 2011·Clinical Neurosurgery·Tiffany A Doucette, Ganesh Rao
Jul 8, 2000·American Journal of Clinical Pathology·C M Abramovich, R A Prayson
Jul 13, 2006·Journal of Molecular Histology·Wiesław MarcolJoanna Lewin-Kowalik
Aug 19, 2010·Journal of Korean Neurosurgical Society·Yong-Hao JinIn-Young Kim
Jun 22, 1999·Human Pathology·R A Prayson

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