Expression of Bcl-2 and p53 correlates with the morphology of gastric neoplasia

The Journal of Pathology
K KyokaneK Kusugami

Abstract

The growth of a tumour can be determined by an interplay between cell proliferation and loss. The expression of apoptosis-related proteins (Bcl-2 and p53), cell proliferation (Ki-67), and apoptotic cell death were investigated using immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling in gastric neoplams, to evaluate whether they correlate with the morphology of the tumour. The materials included ten cases of gastric adenoma and 40 cases of early gastric carcinoma consisting of differentiated adenocarcinomas (n = 20) and undifferentiated carcinomas (n = 20). All cases of adenoma and eight cases of differentiated adenocarcinoma were of the elevated type, while 12 differentiated adenocarcinomas and all of the undifferentiated carcinomas were of the depressed type. The diffuse expression of Bcl-2 was observed in all cases of adenoma and seven out of eight (88 per cent) of elevated-type differentiated adenocarcinoma. In contrast, Bcl-2 expression was absent or focal in the depressed type of carcinoma. Overexpression of p53 was found exclusively in the depressed type of carcinoma. Thus, Bcl-2 and p53 expression was associated with tumour morphology. It seemed unlikely that Bcl-2 and ...Continue Reading

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Citations

Apr 18, 2014·Journal of Immunology Research·Mariusz GrykoKatarzyna Guzińska-Ustymowicz
Aug 29, 2003·Journal of Clinical Pathology·C J van der WoudeH Moshage
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Susan C AbrahamTsung-Teh Wu
Jun 7, 2015·BMC Gastroenterology·Shoko MinemuraOsamu Yokosuka
Dec 20, 2002·International Journal of Surgical Pathology·João Pinto-de-SousaAmadeu Pimenta
Dec 12, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G PomaraC Selli
Mar 19, 2004·Pathology Oncology Research : POR·Funda ErenBahadir Güllüoğlu
Feb 24, 2001·The American Journal of Gastroenterology·H H Xia, N J Talley
Dec 14, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhe JinTeiichi Motoyama
Nov 22, 2005·The Korean Journal of Internal Medicine·Jee Hyun ParkMi Sung Kim
Apr 25, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Toshihiko NakamuraYoshihiko Maehara

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