Expression of bcl-2 in fetal thymus, thymomas and thymic carcinomas. Association with p53 expression and review of the literature

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
P EngelN Graem

Abstract

Bcl-2 is a proto-oncogene inhibiting apoptosis, and p53 is a tumor supressor gene which induces apoptosis. Both seem to take part in tumorigenesis. An inverse relationship between the two genes has been reported in some neoplasms, although the exact mechanism is not fully understood. We have analyzed the expression of bcl-2 and p53 in 18 fetal thymuses and 18 clinically benign and malignant thymomas: bcl-2 was expressed by most medullary lymphocytes and epithelial cells of the normal thymus; p53 was not expressed at all. Bcl-2 and p53 were co-expressed in the majority of the thymomas and the staining reaction was stronger in the clinically malignant ones. It is concluded that although co-expression of bcl-2 and p53 is of doubtful prognostic relevance, the staining pattern of bcl-2 supports the histogenetic classification system of Müller-Hermelink.

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Citations

Nov 24, 1999·The American Journal of Medicine·P SaikumarM A Venkatachalam
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronan J KellyGiuseppe Giaccone
Oct 13, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Maria BaiPanagiotis Kanavaros
Aug 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annikka WeissferdtCesar A Moran
Jun 3, 2008·Hematology/oncology Clinics of North America·Elisabetta Kuhn, Ignacio I Wistuba
Sep 18, 2002·Pathology, Research and Practice·Sung-Hye ParkJae Y Ro
Mar 22, 2015·Clinical and Experimental Medicine·Alexandra Papoudou-BaiPanagiotis Kanavaros
Jun 8, 2014·Medical Oncology·J SyriosA E Athanasiou
Jun 3, 2014·PloS One·Rafaela Rosa-RibeiroHernandes F Carvalho
Nov 25, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anthony A GalCynthia Cohen
Dec 14, 2019·World Journal of Clinical Cases·Bei WangDing-Rong Zhong

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