PMID: 8943742Oct 1, 1996Paper

Expression of bcl-2 oncoprotein in pituitary tumours: comparison with c-myc

Journal of Clinical Pathology
D G WangK D Buchanan

Abstract

Whereas the control of hormone secretion from pituitary adenomas has been studied in considerable detail, the molecular events underlying the development of these tumours are still poorly understood. Abnormalities of some oncogenes and tumour suppressor genes have been previously reported to occur at very low frequencies. The aim of the present study was to assess the possible expression of the bcl-2 oncoprotein and to compare it with that of c-myc in pituitary adenomas. Monoclonal antibodies were used, along with microwave antigen retrieval and the avidin-biotin immunohistochemical method, to investigate expression of the oncoproteins bcl-2 and c-myc in 30 primary pituitary tumours from five broad diagnostic groups and in five normal pituitaries. Bcl-2 and c-myc immunoreactivities were detected in nine (30%) and eight (27%) tumour samples, respectively. Of the nine bcl-2 and eight c-myc positive tumours, seven were positive for both oncoproteins and included one of the four corticotrophinomas studied, four of seven prolactinomas, one of two somatotrophinomas, and one of four oncocytomas. All 13 null cell adenomas studied were negative for both bcl-2 and c-myc immunoreactivities. These results indicate that the bcl-2 and c-myc ...Continue Reading

References

Apr 1, 1992·The Journal of Clinical Endocrinology and Metabolism·H J KargaJ L Jameson
Apr 3, 1992·Cell·G I EvanD C Hancock
Jul 1, 1990·The Journal of Clinical Investigation·J M AlexanderA Klibanski
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·V HermanS Melmed
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E V SchmidtP Leder
Jan 16, 1987·Science·J M Bishop
Sep 1, 1993·The Journal of Clinical Endocrinology and Metabolism·V L CrynsA Arnold
Jul 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M WoloschakK Post
Jul 1, 1993·The Journal of Clinical Endocrinology and Metabolism·V HermanS Melmed
Jan 1, 1993·Molecular Carcinogenesis·T J McDonnell
Jan 1, 1994·Clinical Endocrinology·R RaghavanP Kendall-Taylor
Apr 1, 1993·Molecular and Cellular Biology·A J WagnerN Hay

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Citations

Jun 8, 2011·Endocrine Pathology·Milani SivapragasamKalman Kovacs
Feb 14, 2012·Endocrine Pathology·Robert FormosaJosanne Vassallo
May 16, 2003·Tissue & Cell·Maria del Pilar AokiCristina A Maldonado
Jan 24, 2002·The Journal of Clinical Investigation·Anthony P HeaneyShlomo Melmed
Nov 1, 2005·Neurosurgical Focus·John A Jane
Aug 5, 2015·Pituitary·Justin SeltzerJohn D Carmichael
Jul 30, 2015·Endocrine-related Cancer·Katharina LampichlerSabina Baumgartner-Parzer
Aug 16, 2016·Medical Hypotheses·Walter Geoffrey Roper
Sep 1, 1999·Clinical Endocrinology·D G Wang
Dec 9, 1997·The Journal of Pathology·D G WangK D Buchanan
Sep 11, 2004·British Dental Journal·V R FirmstoneJ Hall
Feb 28, 2006·Journal of Pineal Research·Quan-Hui YangShiu-Fun Pang
Mar 19, 2004·Neurosurgery·Arthur J UlmAlbert L Rhoton

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