Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients

American Journal of Clinical Pathology
Michael T BurkeNicole M Isbel

Abstract

This study aims to investigate how immunosuppression influences the protein expression of antiapoptotic members of the Bcl-2 family-namely, Bcl-xL and Mcl-1-in nonmelanoma skin cancer (NMSC) and the peritumoral epidermis of renal transplant recipients. NMSC and peritumoral epidermis protein expression of Bcl-xL and Mcl-1 were assessed by immunohistochemistry in renal transplant recipients receiving tacrolimus or sirolimus and the general population not receiving immunosuppression. NMSC from renal transplant recipients compared with patients not receiving immunosuppressant medications had a reduced Bcl-xL expression intensity (P = .042). Mcl-1 expression intensity in NMSC was decreased in tacrolimus-treated patients compared with sirolimus-treated patients and the nonimmunosuppressed population (P = .024). Bcl-xL expression intensity was increased in peritumoral epidermis compared with NMSC (P = .002). It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimus-treated patients.

References

Apr 20, 1999·Archives of Otolaryngology--head & Neck Surgery·M A HotzM M Borner
Mar 20, 2001·American Journal of Human Genetics·M T BastiaensUNKNOWN Leiden Skin Cancer Study Team
May 25, 2002·Cancer Investigation·Glenda GobéRalph Buttyan
Mar 8, 2003·Archives of Dermatology·Juan-Carlos MartinezUNKNOWN Transplant-Skin Cancer Collaborative
May 29, 2004·The American Journal of Dermatopathology·Anneli R BowenDouglas Grossman
Oct 27, 2004·Apoptosis : an International Journal on Programmed Cell Death·D AguirreE Raymond
Jan 26, 2005·Journal of Neuroscience Research·O Nesic-TaylorJ R Perez-Polo
Oct 7, 2005·The Journal of Biological Chemistry·Jill Kuglin SchweitzerCrislyn D'Souza-Schorey
Feb 1, 2006·The British Journal of Dermatology·F J MoloneyG M Murphy
Feb 27, 2007·Oncogene·J M Adams, S Cory
Mar 27, 2007·Cell·Kylie D MasonBenjamin T Kile
Sep 8, 2007·The Journal of Biological Chemistry·Marc Germain, Vincent Duronio
Oct 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F J DuncanAnne M Vanbuskirk
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian I Rini
Jul 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·John R MillsJerry Pelletier
Nov 28, 2008·The Journal of Investigative Dermatology·Leonid A SitailoMitchell F Denning
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Feb 23, 2010·Lancet·Vishal MadanRolf-Markus Szeimies
Mar 25, 2011·Indian Journal of Dermatology·Saumya Panda
Aug 20, 2011·Expert Opinion on Investigational Drugs·Bridget A QuinnPaul B Fisher
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew W RobertsRod Humerickhouse
Jan 28, 2012·Cancer Letters·Kris Nys, Patrizia Agostinis
Feb 2, 2012·The Journal of Clinical Investigation·Vladimir RatushnyJohn T Seykora
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S B CampbellG R Russ
Apr 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles M RudinLeena Gandhi
Jul 27, 2012·The New England Journal of Medicine·Sylvie EuvrardUNKNOWN TUMORAPA Study Group
Nov 7, 2012·Cancer Prevention Research·Theresa D CarrLisa M Shantz
Dec 5, 2012·Apoptosis : an International Journal on Programmed Cell Death·Pietro E CippàThomas Fehr
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Robert P CarrollPaul N Harden
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith M Hoogendijk-van den AkkerJohan W de Fijter
Jun 22, 2013·Genes & Development·Xi WangJoseph T Opferman
Dec 21, 2013·Nature Reviews. Molecular Cell Biology·Peter E CzabotarJerry M Adams
Mar 25, 2014·Pigment Cell & Melanoma Research·Nethia Mohana-KumaranNikolas K Haass

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.