Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low-avoidance) and resistance (Roman high-avoidance) to stress-induced depression

Brain and Behavior
M Pina SerraMarina Quartu

Abstract

The selective breeding of Roman High- (RHA) and Low-Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress-induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders. Western blot (WB) and immunohistochemistry were used to investigate the basal immunochemical occurrence of brain-derived neurotrophic factor (BDNF) and its high-affinity tyrosine-kinase receptor trkB in the dorsal and ventral hippocampus of adult RHA and RLA rats. WB analysis indicated that the optical density of BDNF- and trkB-positive bands in the dorsal hippocampus is, respectively, 48% and 25% lower in RLA versus RHA rats. Densitometric analysis of BDNF- and trkB-like immunoreactivity (LI) in brain sections showed that BDNF-LI is 24% to 34% lower in the different sectors of the Ammon's ho...Continue Reading

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Citations

Aug 7, 2019·Journal of Neuroscience Research·Eric Zhang, Ping Liao
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroki IshiguroEmmanuel S Onaivi
Aug 28, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Renata B PetersGabriele Ghisleni
Feb 20, 2021·Neuropsychiatric Disease and Treatment·Yuhuan LiZongjun Guo
Feb 23, 2020·Biochemical and Biophysical Research Communications·Qiu-Ling WuWei-Dong Zhang

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Methods Mentioned

BETA
electrophoresis

Key Resources (RRID) Mentioned

AB_630940
AB_632557
AB_258434
AB_2107445
AB_90456
SCR_014211
AB_2313606
SCR_003070

Software Mentioned

Image Studio Lite
ImageJ
ImageQuant

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