Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent

Cellular and Molecular Neurobiology
D I PeregudN V Gulyaeva

Abstract

Nitric oxide (NO) mediates pharmacological effects of opiates including dependence and abstinence. Modulation of NO synthesis during the induction phase of morphine dependence affects manifestations of morphine withdrawal syndrome, though little is known about mechanisms underlying this phenomenon. Neurotrophic and growth factors are involved in neuronal adaptation during opiate dependence. NO-dependent modulation of morphine dependence may be mediated by changes in expression and activity of neurotrophic and/or growth factors in the brain. Here, we studied the effects of NO synthesis inhibition during the induction phase of morphine dependence on the expression of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and insulin-like growth factor 1 (IGF1) as well as their receptors in rat brain regions after spontaneous morphine withdrawal in dependent animals. Morphine dependence in rats was induced within 6 days by 12 injections of morphine in increasing doses (10-100 mg/kg), and NO synthase inhibitor L-N(G)-nitroarginine methyl ester (L-NAME) (10 mg/kg) was given 1 h before each morphine injection. The expression of the BDNF, GDNF, NGF, IGF1, and their receptors in t...Continue Reading

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Citations

May 18, 2016·Neurobiology of Disease·Maryna KoskelaMikko Airavaara
Mar 18, 2017·Reviews in the Neurosciences·Raul Felipe Palma-ÁlvarezCarlos Roncero
Oct 21, 2019·Metabolic Brain Disease·Mohammad Taghi MansouriSoheila Alboghobeish
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shan LiuHuali Xu

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