PMID: 20635044Jul 17, 2010Paper

Expression of beta-catenin during premaxillary suture distraction osteogenesis in rat

Shanghai kou qiang yi xue = Shanghai journal of stomatology
Hai-xia LiuGuo-hua Tang

Abstract

beta-catenin, as a glycoprotein in cytoplasm, was involved in osteoblast development and bone formation. This study was designed to observe the spacial and temporal expression of beta-catenin during premaxillary suture distraction osteogenesis in rat. Thirty two female SD rats were randomly allotted into experimental group (n=20) and control group (n=12). The experimental animals were subjected to premaxillary suture distraction by helix springs. They were sacrificed on the day 1, 3, 5 and 7. Toluidine blue staining was used to observe the morphology and distribution of the osteoblasts. The expression of beta-catenin and osteopontin (OPN) was identified by immunohistochemical staining. During nature growth, osteoblasts were sparsely lining along the premaxillary suture. beta-catenin immunostaining was mainly localized in the membrane of these cells. The width of the suture was enlarged 1 day after distraction and osteoblasts were accumulated along the suture. Most of these osteoblasts showed positive OPN and beta-catenin immunostaining. beta-catenin signals were expressed additionally in the cytoplasm of the osteoblast and were more intensive in experimental sutures than those in control animals. New bone deposition was identif...Continue Reading

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