PMID: 9663855Jul 15, 1998Paper

Expression of blood group antigens A and/or B in diseased corneas

Current Eye Research
N ArdjomandH Radner

Abstract

Only epithelial cells are thought to express blood group antigens (bga) A and/or B in normal corneas, and ABO blood group (bg) matching seems to reduce immune rejection in high risk transplantations. This study attempts for the first time to investigate to what extent the bga A and/or B are expressed in diseased corneas. Thirty-nine diseased corneal buttons of 39 patients were examined. Immunohistochemical staining of paraffin-embedded sections was performed with monoclonal mouse anti human blood groups A and B antibodies using the Streptavidin-Biotin-peroxidase complex technique (LSAB Kit, Dako). The expression of blood group antigens A and/or B on the cornea was found to correlate directly with the blood group of the patients in all cases. The corneal epithelium of all 18 patients with blood groups A and/or B could be stained with antibodies to bga A and/or B. However, neither bga A nor bga B could be detected in any corneal cells of patients with the blood group O (21 patients). In addition to the epithelium, the stromal keratinocytes as well as the endothelium contained immunohistochemically detectable bga A and/or B in cases of keratitis or keratoconus, but not in stromal and/or endothelial cells of corneas with pseudophak...Continue Reading

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Citations

Dec 6, 2008·American Journal of Ophthalmology·Steven P DunnUNKNOWN Cornea Donor Study Investigator Group
Dec 17, 2014·Eye & Contact Lens·Mohammad NaderanRozhin Pahlevani
Apr 7, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N ArdjomandH Radner

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