Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370

FEBS Letters
Tomohiro ItohYukihiro Akao

Abstract

MicroRNAs (miRs) regulate several biological functions such as cell growth, cell differentiation, and carcinogenesis, by binding to the 3'-untranslated regions (3'-UTR) of specific target genes, in order to repress translation or promote degradation of the transcribed mRNAs. In the present study, using microRNA array and in silico analyses, we found that miR-370 regulates the expression of bone morphogenetic protein-2 (BMP-2) and V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Ets1) in BMP-2-stimulated murine pre-osteoblast MC3T3-E1 cell differentiation. The enforced expression of mature miR-370 in MC3T3-E1 cells or primary osteoblast cells remarkably attenuated BMP-2-induced pre-osteoblast differentiation. To ascertain the mechanisms underlying the regulation of osteoblast differentiation by miR-370, we hypothesized a BMP-2-Ets1-PTHrP feed-forward loop regulatory mechanism.

References

Feb 15, 2001·Oncogene·A Raouf, A Seth
Feb 15, 2001·Oncogene·M Trojanowska
Feb 15, 2001·Oncogene·J S Yordy, R C Muise-Helmericks
Jan 30, 2002·Gene·John T SwarthoutNicola C Partridge
Jul 10, 2003·Molecular and Cellular Endocrinology·Christophe CataissonZhor Bouizar
Jul 19, 2003·Science·James C Carrington, Victor Ambros
Sep 16, 2003·Molecular Cancer·Jürgen Dittmer
Sep 17, 2004·Nature·Victor Ambros
Dec 2, 2004·Molecular and Cellular Biology·Charles E FouldsBarbara J Graves
Dec 29, 2004·Growth Factors·Di ChenGregory R Mundy
Aug 30, 2005·Gene·Xu Cao, Di Chen
May 4, 2006·The Journal of Biological Chemistry·Philip Y WaiPaul C Kuo
Aug 3, 2006·Current Medical Research and Opinion·P ten Dijke
Sep 15, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jan H SchefeHeiko Funke-Kaiser
Feb 27, 2007·Molecular and Cellular Endocrinology·Hinda HamzaouiZhor Bouizar
Nov 6, 2007·The Journal of Biological Chemistry·Shinu A JohnLee Ann Garrett-Sinha
Aug 30, 2008·Cells, Tissues, Organs·Renny T FranceschiDi Jiang
Mar 3, 2009·Cellular Signalling·Nabanita S Datta, Abdul B Abou-Samra
Apr 4, 2009·Biochemical and Biophysical Research Communications·Mari M SatoMasato Tamura
Jun 13, 2009·FEBS Letters·Yosuke MizunoYasushi Okazaki
Aug 13, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H TakaseT Sugimoto
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hiroyuki InoseShu Takeda
Jan 19, 2010·Carcinogenesis·Yutaka HashimotoYasuhito Yuasa
Jan 28, 2010·Journal of Cell Science·Stephanie B GreeneJeffrey M Rosen
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chunnian ZhaoYanhong Shi
Aug 14, 2010·Molecular Cell·Thomas Treiber, Gunter Meister
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tilde EskildsenMoustapha Kassem

❮ Previous
Next ❯

Citations

Dec 7, 2013·Journal of Bone and Mineral Metabolism·Xin ZhaoXiaodong Xie
Aug 12, 2014·Cellular and Molecular Life Sciences : CMLS·Garyfallia PapaioannouTatsuya Kobayashi
Dec 25, 2012·The International Journal of Biochemistry & Cell Biology·Raghu BhushanPetra Knaus
Mar 11, 2016·Connective Tissue Research·Supaporn Suttamanatwong
Jan 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claudine SeeligerMartijn van Griensven
Mar 18, 2015·Journal of Cellular Biochemistry·Melissa B RogersNadia N Shaikh
Jul 21, 2015·Progress in Neurobiology·Shane V HegartyGerard W O'Keeffe
Feb 18, 2015·Digestive Diseases and Sciences·Cui-Hua LuXin Zhang
Jan 13, 2015·International Journal of Molecular Medicine·Akiko Hata, Hara Kang
Jul 16, 2016·Stem Cells and Development·Claudine SeeligerMartijn van Griensven
Jul 19, 2016·Cell and Tissue Research·Cong HuangSiwen Jiang
Nov 21, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Ming YuShi-Bi Lu
Dec 20, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Peter VrtačnikBarbara Ostanek
May 10, 2019·Journal of Cellular Biochemistry·Tayebe Moghaddam, Zeinab Neshati
Jul 11, 2019·Current Molecular Biology Reports·Benjamin J WildmanQuamarul Hassan
Oct 6, 2020·Frontiers in Pharmacology·Yali RenCheng Peng
Aug 18, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mathieu BorelSaida Mebarek
Mar 7, 2021·International Journal of Molecular Sciences·Chiara MazziottaFernanda Martini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.