Expression of BMP7 is associated with resistance to diabetic stress: comparison among mouse salivary glands

European Journal of Pharmacology
Masatake IzumiMitsuru Kawaguchi

Abstract

We determined mRNA levels of bone morphogenetic protein 7 (BMP7), a growth and differentiation factor belonging to the transforming growth factor-beta superfamily, in the salivary glands of mice with streptozotocin (200 mg/kg, i.p.)-induced diabetes. We also examined the effects of BMP7 on secretion of saliva and degenerative change in salivary glands in diabetic mice. In normal mice, BMP7 mRNA levels were high in the submandibular gland and low in the parotid gland, while in diabetic mice, levels were significantly decreased in the parotid gland, but not in the submandibular gland. No significant difference was observed in mRNA levels of BMP receptors between normal and diabetic mice. In diabetic mice, pilocarpine (4 mg/kg, i.p.)-stimulated salivary secretion showed a remarkable decrease in both parotid and submandibular gland, although degree of reduction was smaller in the latter. Notable degeneration with vacuolation and atrophy was also found in parotid gland, whereas degeneration of submandibular gland was slight. Administration of BMP7 (50 and 100 microg/kg, i.v.) in diabetic mice induced a significant increase in salivary secretion, with rate of recovery higher in parotid gland than in submandibular gland. In diabetic m...Continue Reading

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Citations

Feb 5, 2011·European Journal of Pharmacology·Kazunori OuchiMitsuru Kawaguchi
Jan 12, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Linda SpiegelbergKarel G H van der Wal
Mar 27, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toshiya SatoHisayoshi Ishii
Aug 17, 2017·Journal of Receptor and Signal Transduction Research·Kensuke NishioMasatake Asano
Dec 4, 2020·International Journal of Molecular Sciences·Xianglan ZhangEunae Sandra Cho
Jul 3, 2021·Journal of Molecular Histology·Malak FouaniAngelo Leone

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