Expression of bone morphogenetic protein-10 mRNA during chicken heart development

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Semir SomiMaurice J B Van Den Hoff

Abstract

In this communication we describe the expression pattern of BMP10 mRNA during cardiac development in chickens. BMP10 is considered an important factor in the regulation of cardiac growth and trabeculation in the murine embryo. We identified chicken Ests, which are similar to mouse and human BMP10 in the UMIST database. The cDNA clone that contained most sequences was obtained, verified by sequence analysis, and used to determine the spatiotemporal pattern of gene expression. BMP10 mRNA is initially expressed at HH10 in the myocardium of the arterial pole of the heart tube, anterior to the interventricular groove. Between HH14 and HH22, BMP10 mRNA becomes broadly expressed in the outflow tract, the distal part of the inflow tract, and the trabeculated part of the developing ventricles and atria. From HH31 onward, BMP10 mRNA expression decreases in the ventricular myocardium by first disappearing from the compact myocardium and then from the tips of the trabecules. At HH44, BMP10 mRNA is expressed only in the trabeculated myocardium of the atria and the endocardium of the ventricles. The observed expression pattern of BMP10 mRNA suggests that it may play a role in regulating the formation of the ventricular wall and trabecules.

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Citations

Nov 20, 2012·Cellular and Molecular Life Sciences : CMLS·Victoria C GarsidePamela A Hoodless
Jun 5, 2012·Differentiation; Research in Biological Diversity·Boudewijn P T KruithofMarie-José Goumans
Jun 7, 2006·Developmental Biology·Boudewijn P T KruithofMaurice J B van den Hoff
Sep 6, 2017·Cellular and Molecular Life Sciences : CMLS·Beth L Roman, Andrew P Hinck
Jun 6, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gert van den BergMaurice J B van den Hoff
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roong Zhao, Stephen A Duncan
Aug 17, 2016·Biochemical Society Transactions·Wei LiNicholas W Morrell
Nov 13, 2019·The Journal of Biological Chemistry·Xiuxia QuHanying Chen
Jul 10, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Agnès Desroches-CastanSabine Bailly

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