PMID: 9532004Apr 9, 1998Paper

Expression of bone morphogenetic proteins in salivary pleomorphic adenomas

Virchows Archiv : an International Journal of Pathology
K KusafukaT Takemura

Abstract

Salivary pleomorphic adenomas are often associated with chondroid tissue formation. We investigated the relationship between chondroid tissue formation and the expression of bone morphogenetic proteins (BMPs), which are strong inducers of ectopic bone and cartilage formation. Fifteen pleomorphic adenomas and seven normal salivary glands were examined genetically and immunohistochemically. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that BMP-1, BMP-2, BMP-3, BMP-4, and BMP-7 mRNAs were overexpressed in 10 (66.7%), 9 (60.0%), 1 (6.7%), 8 (53.3%), and 12 (80.0%), respectively, of the 15 pleomorphic adenomas. Overexpression of BMP-2 mRNA was observed in pleomorphic adenomas. Marked chondroid formation or expression of type II collagen was frequently observed in pleomorphic adenomas that overexpressed BMP-2 mRNA. Immunohistochemically, BMP-2 was detected in modified myoepithelial cells aroud chondroid tissue and basement membranes. These results suggest that BMPs, and expecially BMP-2, have a role in chondroid formation in pleomorphic adenomas.

Citations

Nov 19, 2004·Virchows Archiv : an International Journal of Pathology·Kimihide KusafukaSusumu Ikehara
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tetsuya NakataniMasahiro Kurosaka
Feb 15, 2002·Pathology International·H ShigeishiW Yasui
Dec 29, 2007·BMC Musculoskeletal Disorders·Iwona KochanowskaKazimierz Ostrowski
Mar 27, 2010·Journal of Oral Science·Matti LaaksonenTuula Salo
Dec 14, 2001·Biochemical and Biophysical Research Communications·H YonouA Ochiai
Oct 27, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuka MatsumotoYuzo Ogawa
Aug 7, 2010·Cytokine & Growth Factor Reviews·Ashok Singh, Rebecca J Morris
Oct 20, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gul San Ara SathiNoriyuki Nagai
Jan 9, 2004·Oncogene·Marianne L VozWim J M Van de Ven
Aug 15, 2015·Spine·Branko SkovrljSamuel K Cho
Sep 2, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K KusafukaT Takemura
Apr 23, 2003·Virchows Archiv : an International Journal of Pathology·Kimihide KusafukaTamiko Takemura

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