Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Shinichi KimuraIsamu Okamoto

Abstract

TrkB is a receptor for brain-derived neurotrophic factor (BDNF) and is highly expressed in various cancers, with BDNF-TrkB signaling having been implicated in tumor progression and metastasis. The role of the BDNF-TrkB system in small cell lung cancer (SCLC), a neuroendocrine cancer, has remained unclear, however. We examined BDNF and TrkB expression in SCLC patients as well as the function of BDNF-TrkB signaling in SCLC cell lines. BDNF and TrkB expression in tumor specimens of 58 SCLC patients and 20 non-small cell lung cancer (NSCLC) patients was examined by immunohistochemistry and was scored on the basis of the distribution and intensity of staining. TrkB-overexpressing SCLC (SBC5TrkB) cells were established by retrovirus transduction and were examined for the effects of BDNF on intracellular signaling, cell proliferation, and cell migration in vitro. The staining score for TrkB in NSCLC and SCLC specimens was 2.80 ± 0.19 and 3.60 ± 0.15, respectively, whereas that for BDNF was 1.95 ± 0.32 and 2.76 ± 0.14, respectively. High levels of both TrkB and BDNF expression in SCLC tumors were significantly associated with poor overall survival in multivariate analysis (hazard ratio = 1.821, P = 0.036). BDNF activated AKT and ERK si...Continue Reading

Citations

Apr 10, 2019·Current Alzheimer Research·Radhika KhoslaAkshay Anand
Sep 11, 2020·Cancers·Amanda ThomazRafael Roesler
Dec 2, 2020·Biomedicines·Vivian P WagnerLynne Bingle
Dec 10, 2020·BioMed Research International·Mariangela LombardiAlberto Ricci
Aug 5, 2020·Current Cancer Drug Targets·Wujun ZouLiang Jiang
Sep 18, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Florencia M L DornellesManoela D Martins
Dec 11, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ashlee LongDeeann Wallis
Sep 11, 2020·Cytokine·Vilson Serafim JuniorEny Maria Goloni-Bertollo

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