PMID: 9447914Feb 3, 1998Paper

Expression of brain-derived neurotrophic factor and its receptor mRNA in the vestibuloauditory system of the bullfrog

Hearing Research
D M DonP Popper

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been suggested to play a crucial role in the development and maintenance of the inner ear. In the present study, we investigated the expression of mRNAs of BDNF and its high-affinity receptor trkB in the vestibuloauditory system of the adult bullfrog. In situ hybridization was performed using riboprobes transcribed from Xenopus BDNF and trkB cDNA clones. BDNF mRNA was expressed in the sensory epithelia of the ampullary cristae, utricular and saccular maculae, lagena, and amphibian and basilar papillae. Strong hybridization for BDNF mRNA was also found in neuron somata of the vestibuloauditory nuclear complex. trkB mRNA was detected in the sensory epithelia of all vestibular and auditory endorgans. High levels of both BDNF and trkB mRNAs were found in vestibuloauditory ganglion cells. These results support the hypothesis that BDNF participates in the maintenance of vestibuloauditory neurons and may be important for the trophic regulation of vestibular and auditory sensory epithelia in this animal model.

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Citations

Oct 19, 1999·The Journal of Comparative Neurology·S L CochranE W Rubel
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeannie H ReyesRichard A Altschuler
May 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A R Del Angel-MezaC Beas-Zárate
Aug 19, 2020·International Journal of Molecular Sciences·Antonino GermanàFrancesco Abbate

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