Expression of BRCA1 protein in breast cancer and its prognostic significance

Human Pathology
Emad A RakhaIan O Ellis

Abstract

BRCA1 is a tumor suppressor gene which, when mutated, is associated with the development of hereditary breast cancers. In sporadic tumors, although inherent gene mutations are rare, loss of BRCA1, resulting from reduced expression or incorrect subcellular localization, is postulated to be important. The purpose of the current study was to examine the expression and localization of BRCA1 protein and to assess its prognostic value, in a well-characterized series of unselected breast carcinomas. We have examined BRCA1 in a series of invasive breast carcinoma (1940 cases) using tissue microarray and immunohistochemistry, to evaluate its expression pattern and to correlate this with clinicopathologic variables and patient outcome. In breast cancer, complete loss of nuclear expression was observed in 223 cases (15%) and cytoplasmic expression was found in 541 breast cancers (36.6%). Absent or reduced nuclear BRCA1 expression was observed more frequently in ductal carcinoma of no special type and medullary-like carcinoma and less frequently in lobular and tubular mixed carcinomas. It was also associated with high-grade, advanced lymph node stage, larger size, vascular invasion, negative estrogen receptor, progesterone receptor and and...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·M H GaleaI O Ellis
Jun 1, 1997·Nature Genetics·E CoeneC R De Potter
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·J TaylorS Ali
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·L T SeeryR I Nicholson
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KolliasR W Blamey
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunil R LakhaniDouglas F Easton
Mar 21, 2003·Journal of Cellular Biochemistry·Kumaravel Somasundaram
May 20, 2003·The Journal of Pathology·H LambieI O Ellis
Jun 5, 2003·Breast Cancer Research and Treatment·Monique ChambonFrançoise Vignon
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
May 14, 2004·The Journal of Pathology·Dalia M Abd El-RehimIan O Ellis
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Oct 29, 2004·Nature Reviews. Cancer·Nicholas TurnerAlan Ashworth
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarle B ArnesWilliam D Foulkes
Jun 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emad A RakhaIan O Ellis
Jul 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mervi LaaksoJorma Isola
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Sep 26, 2006·Oncogene·N C Turner, J S Reis-Filho
Oct 4, 2006·Oncogene·N C TurnerA N Tutt
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A CareyCharles M Perou

❮ Previous
Next ❯

Citations

Jun 19, 2012·Breast Cancer Research and Treatment·Sylvie M NoordermeerBert A van der Reijden
Sep 21, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gulisa TurashviliSamuel A J R Aparicio
Jan 10, 2009·Nature Reviews. Cancer·Barry Gusterson
Feb 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A MangiaF Darvishian
Aug 23, 2011·Cancer Cell International·Johanne I WeberpalsJim Dimitroulakos
Jul 17, 2013·Cancer Cell International·Natalie TulchinAlvaro Na Monteiro
Apr 19, 2012·PloS One·Yoshiko ShimizuWael M ElShamy
Mar 19, 2014·Cancers·Lori E Lowes, Alison L Allan
Jan 23, 2010·Breast Cancer Research and Treatment·Edith A PerezCathy A Andorfer
Feb 19, 2010·The Cancer Journal·Elizabeth A Comen, Mark Robson
Aug 13, 2008·Expert Opinion on Therapeutic Targets·Kai-Keen ShiuJorge S Reis-Filho
Jul 25, 2015·International Journal of Cancer. Journal International Du Cancer·Giulia PartipiloAnita Mangia
Jan 16, 2010·The American Journal of Pathology·Natalie TulchinAlvaro N A Monteiro
Jul 3, 2015·EBioMedicine·Julia Y S Tsang, Gary M K Tse
Feb 24, 2011·Journal of Cellular Physiology·Yunlong QinVeena N Rao
Nov 29, 2011·Enzyme Research·Qingxiu Zhang, Francois X Claret
May 4, 2010·Molecular Oncology·Kevin A KweiJonathan R Pollack
Aug 1, 2015·Molecular Neurodegeneration·Harun Najib NoristaniFlorence Evelyne Perrin
Jun 10, 2015·British Journal of Cancer·W L SantivasiFen Xia
Jun 28, 2013·PloS One·Estelle DacheuxNicole Dalla Venezia
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.