Expression of BUBR1 in human oral potentially malignant disorders and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Pi-Chuan HsiehSheng-Fung Lin

Abstract

BUBR1 is one of the key components of the spindle assembly checkpoint (SAC) machinery and is activated in response to kinetochore tension. Defects in the SAC contribute to an increased rate of aneuploidization during tumorigenesis. The aim of the present study was to examine the immunohistochemical expression of BUBR1 protein for human oral squamous cell carcinogenesis. A total of 120 samples of squamous cell carcinoma (SCC, n = 43) and 5 types of potentially malignant disorders (PMDs: oral epithelial dysplasia, n = 11; hyperkeratosis/epithelial hyperplasia, n = 20; lichen planus, n = 16; submucous fibrosis, n = 19; and verrucous hyperplasia, n = 11) of human oral mucosa (1991-2001) from our institution were retrieved and immunohistochemical staining were performed. Normal oral mucosa (n = 9) and fibrous hyperplasia (n = 9) from patients without the aforementioned oral habits were also included in the study. BUBR1 staining was detected at the basal and suprabasal layers in 75 (97.4%) of 77 samples of PMD and 43 (100%) of 43 samples of SCC of oral mucosa but was absent in all samples of normal oral mucosa (n = 9) and fibrous hyperplasia (n = 9). BUBR1 expression of various types of PMD and SCC of oral mucosa was significantly ov...Continue Reading

References

Mar 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J J PindborgF S Mehta
Aug 1, 1985·Journal of Oral Pathology·A Wright, M Shear
Oct 15, 1980·Cancer·M Shear, J J Pindborg
Apr 10, 1997·Nature·C LengauerB Vogelstein
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Jul 8, 1999·Cancer Letters·K YamaguchiD Sidransky
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·W S SaundersS M Gollin
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A SkoufiasR L Margolis
Jun 16, 2001·International Journal of Cancer. Journal International Du Cancer·E HernandoC Cordon-Cardo
Nov 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masahiro SeikeShoji Kudoh
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Khalid M MinhasJoseph A Califano
Jun 23, 2004·Nature Genetics·Darren J BakerJan M van Deursen
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chinthalapally V RaoWei Dai
May 5, 2005·Molecular and Cellular Biology·Tatsuo OikawaKenji Fukasawa
Nov 29, 2005·Oral Oncology·W M TilakaratneSaman Warnakulasuriya
Aug 15, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Micaela Poetsch, Britta Kleist
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Takuya MatsumotoJan M van Deursen
Mar 14, 2007·Cancer Genetics and Cytogenetics·Yoshiaki YamamotoKohsuke Sasaki
Oct 26, 2007·Cancer Letters·Eswary ThirthagiriIan C Paterson
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaE Dabelsteen
Jul 9, 2008·Acta Oncologica·Julian Campo-TraperoAntonio Bascones-Martínez

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Citations

Jul 6, 2014·BioMed Research International·José Henrique TeixeiraHassan Bousbaa
Jul 8, 2015·International Journal of Molecular Sciences·Chou-Kit ChouChien-Chih Chiu
Apr 15, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Anja PickhardRudolf Reiter
May 20, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Taneeru SravyaGuttikonda Venkateswara Rao
May 14, 2016·Japanese Journal of Clinical Oncology·Yoshiaki YamamotoHideyasu Matsuyama
Jun 4, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andressa Gois MoralesLuiz Gonzaga Tone

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