Expression of c-fos protein by N-methyl-D-aspartic acid in hypothalamus of immature female rats: blockade by MK-801 or neonatal treatment with monosodium glutamate

Brain Research. Developmental Brain Research
M C MacdonaldM Wilkinson

Abstract

Significant NMDA-induced cellular activity in the median eminence-arcuate region of immature female rats was immunocytochemically localized via c-fos protein-like immunoreactivity. The production of this protein was completely prevented by pre-injection of MK-801 or APV, antagonists of the NMDA receptor-coupled ion channel. Treatment of newborn rats with monosodium glutamate (MSG), which destroys glutamate-sensitive neurons, significantly attenuated NMDA-induced c-fos when tested in the peripubertal period. These results implicate NMDA receptors in the expression of c-fos protein-like immunoreactivity in cells of the arcuate nucleus-median eminence of immature female rats.

References

Mar 26, 1990·Neuroscience Letters·M Dragunow, R L Faull
Mar 13, 1990·European Journal of Pharmacology·E Cattaneo, A Maggi
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M PlantM Arslan

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Citations

Jul 16, 1993·Brain Research. Developmental Brain Research·H M SchellinckM Wilkinson
Feb 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E KitrakiF Stylianopoulou
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D W Brann, V B Mahesh
Aug 18, 1997·Brain Research. Developmental Brain Research·M Natarajan, M Wilkinson
Feb 18, 1998·Brain Research. Developmental Brain Research·C E SmythM Wilkinson
Oct 24, 2002·British Journal of Anaesthesia·D MaN P Franks
Apr 17, 1995·The Journal of Comparative Neurology·A YaqubW D Eldred

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