Expression of c-Fos protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine

Alcohol
O Bouchenafa, J M Littleton

Abstract

Male rats were made physically dependent on ethanol by inhalation of the vapour for 10 days, and c-Fos protein-like immunoreactivity was visualised in the brain of these animals after various periods of ethanol withdrawal. Immunostaining for c-Fos appeared 2 h after ethanol withdrawal, the number of cells increased significantly at 8 h, but c-Fos had returned to basal level after 24 h. Immunoreactive cells were distributed throughout the brain but were concentrated in cerebral cortex, striatum, and hippocampus. Intraperitoneal injection of the calcium channel antagonist nifedipine (3 x 100 mg/kg) prior to, and during ethanol withdrawal totally prevented c-Fos protein-like expression. These results suggest that the superinduction of c-Fos protein in the brain of rats undergoing ethanol withdrawal is induced by calcium influx into neuronal cells, and may be related to previously reported increases in L-type voltage-operated calcium channels in the brain associated with ethanol dependence.

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Citations

Feb 2, 2013·Behavior Genetics·Alfredo GhezziNigel S Atkinson
Sep 12, 2007·Cellular and Molecular Neurobiology·Anita Jagota, M Y Reddy
Jan 5, 2001·Alcoholism, Clinical and Experimental Research·M A PrendergastJ M Littleton
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·M A PrendergastJ M Littleton
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Justin A McClain, Kimberly Nixon
Jan 5, 2011·Alcohol·Vivian Taciany BonassoliRúbia Maria Weffort de Oliveira
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Tracy D StepanyanJohn M Littleton
Jun 13, 2006·Brain Research Reviews·Andrey E Ryabinin, Adam Z Weitemier
Sep 18, 2012·European Journal of Pharmacology·Golnaz VaseghiValiollah Hajhashemi

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