Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer

PloS One
Jun-Chao GuoLei You

Abstract

It has long been regarded that pancreatic cancer (PC) is a life-threatening malignant tumor. Thus, much attention has been paid for factors, especially relative molecules, predictive for prognosis of PC. However, c-fos expression in PC was less investigated. In addition, its association with clinicopathologic variables and prognosis remains unknown. In the present study, expression of c-fos was detected by tissue microarray-based immunohistochemical staining in cancer and adjacent tissues from 333 patients with PC. The staining results were correlated with clinicopathologic parameters and overall survival. Furthermore, prognostic significance of c-fos in subsets of PC was also evaluated. It was shown that low expression of c-fos was more often in cancer than in adjacent tissues of PC (P<0.001). Besides, high cancerous c-fos expression was significantly associated with tumor site and T stage, whereas peri-neural invasion was of a borderline significant relevance. Log-rank test revealed that high expression of c-fos in cancer tissues was a significant marker of poor overall survival, accompanied by some conventional clinicopathologic variables, such as sex, grade, peri-neural invasion, T and N stages. More importantly, cancerous ...Continue Reading

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Citations

Oct 27, 2018·EMBO Molecular Medicine·Markus LinderMaria Sibilia
Aug 3, 2019·International Journal of Molecular Sciences·Oliver TreeckOlaf Ortmann
Aug 2, 2019·Molecular and Cellular Biochemistry·Sheeja AravindanNatarajan Aravindan
Nov 22, 2019·Frontiers in Molecular Neuroscience·Jorge BaqueroFrida E Kleiman
Oct 1, 2021·Pathology Oncology Research : POR·Muhammad Ihtisham UmarXianju Huang

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS11

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