Expression of c-myb in embryonal carcinoma cells and embryonal stem cells.

Differentiation; Research in Biological Diversity
P J DysonR Watson

Abstract

Mouse c-myb has been implicated in the regulation of differentiation and proliferation of haematopoietic cells. Analysis of the chromatin structure of the promoter region of c-myb in embryonal carcinoma (EC) cells and embryonal stem (ES) cells reveals a DNAse I-hypersensitive site coincident with a site found in c-myb-expressing haematopoietic cells, but absent in murine fibroblasts (which do not express c-myb). EC and ES cells were found to express c-myb mRNA, albeit at a level lower than found in haematopoietic cells. Differentiation of ES cells into embryoid bodies resulted in an elevated level of c-myb expression.

References

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Citations

Oct 1, 1994·Journal of Biomedical Science·S. Potter
Mar 1, 1994·Mutation Research·J R Schlehofer
Jul 25, 1991·Nucleic Acids Research·K M Howe, R J Watson
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A L Katzen, J M Bishop
Apr 24, 2004·The Journal of Biological Chemistry·Wanli LeiScott A Ness
Jan 1, 1993·Molecular and Cellular Biology·G KellerM V Wiles

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