Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis

Journal of the Neurological Sciences
Bernhard DietzscholdEberhard Weihe

Abstract

In situ hybridization, RT-PCR and Northern blot analysis as well immunohistochemistry were used to examine the expression of C1q, a subcomponent of the rat complement system, in brains of rats infected with Borna disease virus (BDV) and rats afflicted with experimental allergic encephalomyelitis (EAE) induced by the adoptive transfer of myelin basic protein specific T cells. C1q mRNA, which was not detected in normal brain, became clearly detectable using RT-PCR analysis by d14 post infection (p.i.) with BDV. Maximal levels of C1q mRNA were reached 21 days p.i. when inflammatory reactions in the brain were also at a peak. Similarly, C1q mRNA was elevated when the clinical symptoms of EAE became evident 5 days following cell transfer. C1q positive cells, as identified by immunohistology, were preferentially localized in grey and white matter of the hippocampus and basolateral cortex. The C1q positive cells resembled microglial cells in morphology. The correlation of C1q expression with the development of neurological disease as well as the dramatic increase of C1q within brain regions with inflammatory lesions suggest that local biosynthesis of C1q may play a role in the pathogenesis of Borna virus induced and autoimmune encepha...Continue Reading

References

Nov 1, 1992·Experimental Neurology·G M PasinettiC E Finch
Jun 1, 1990·The Biochemical Journal·D F LappinK Whaley
Mar 1, 1991·Brain, Behavior, and Immunity·H J Zentel, E Weihe
Sep 1, 1991·Immunology Today·M M Frank, L F Fries
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Dec 15, 1989·Neuroscience Letters·P L McGeerE G McGeer
Jan 1, 1988·Glia·W J StreitG W Kreutzberg
Jan 1, 1986·Annual Review of Immunology·H J Müller-Eberhard

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Citations

Jan 31, 2004·Neurobiology of Disease·Maria I FonsecaAndrea J Tenner
Feb 23, 2002·Molecular Immunology·Cornelia SpethPhilippe Gasque
Feb 27, 1999·Current Opinion in Immunology·A J Tenner
Apr 19, 2002·International Immunopharmacology·Nicholas J LynchWilhelm J Schwaeble
Jun 26, 2002·Viral Immunology·Nannan Chen, Carol Shoshkes Reiss
May 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R Dürrwald, H Ludwig
Jan 22, 2005·Genes, Brain, and Behavior·G ZaiJ L Kennedy
Apr 30, 2010·Journal of Virology·Jane E LibbeyRobert S Fujinami
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie E Benoit, Andrea J Tenner
Jan 23, 2004·Experimental Neurology·Rong Fan, Andrea J Tenner
Jun 22, 1999·Journal of Neuroimmunology·M G WingD A Compston
Nov 17, 1998·Journal of Neuroimmunology·C G HatalskiW I Lipkin
Feb 24, 2011·Journal of Neuropathology and Experimental Neurology·Candan DepboyluGünter U Höglinger
Jun 10, 2003·Annals of the New York Academy of Sciences·Johan van BeekPhilippe Gasque
Dec 17, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Leandro Rodrigo RibeiroLuiz Fernando Freire Royes
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gwyneth ZaiJames L Kennedy
Aug 21, 2003·Journal of Neuroscience Research·Agata MatejukHalina Offner
Dec 9, 1998·FEBS Letters·W J SchwaebleM K Schäfer
Sep 12, 2014·Journal of Leukocyte Biology·Elizabeth V Clarke, Andrea J Tenner
Oct 3, 2008·Journal of Neuroscience Research·Katrin FärberHelmut Kettenmann
Dec 23, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yunhong BaiDiego Cadavid
Aug 3, 2001·Journal of Biomedical Materials Research·P Tengvall, A Askendal
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M K SchäferE Weihe
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giovanna VinciMario Tosi
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johan van BeekPhilippe Gasque

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