Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum)

The Journal of Comparative Neurology
D KrizajDavid Copenhagen

Abstract

Changes in intracellular calcium concentration, [Ca2+]i, modulate the flow of visual signals across all stages of processing in the retina, yet the identities of Ca2+ transporters responsible for these changes are still largely unknown. In the current study, the distribution of plasma membrane and intracellular Ca2+ transporters in the retina of tiger salamander, a model system for physiological studies of retinal function, was determined. Plasma membrane calcium ATPases (PMCAs), responsible for high-affinity Ca2+ extrusion, were highly expressed in the salamander retina. PMCA isoforms 1, 2, and 4 were localized to photoreceptors, whereas the inner retina expressed all four isoforms. PMCA3 was expressed in a sparse population of amacrine and ganglion neurons, whereas PMCA2 was expressed in most amacrine and ganglion cells. Na+/Ca2+ exchangers, a high-capacity Ca2+ extrusion system, were expressed in the outer plexiform layer and in a subset of inner nuclear and ganglion layer cells. Intracellular Ca2+ store transporters were also represented prominently. SERCA2a, a splice variant of the sarcoplasmic-endoplasmic Ca2+ ATPase, was found mostly in photoreceptors, whereas SERCA2b was found in the majority of retinal neurons and in g...Continue Reading

References

Sep 1, 1992·The Journal of Physiology·L LagnadoP A McNaughton
Aug 1, 1992·The American Journal of Physiology·F A LaiG Meissner
Nov 22, 1988·Biochimica Et Biophysica Acta·K D PhilipsonR Ward
Jan 1, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Lasansky
May 1, 1969·Journal of Neurophysiology·F S Werblin, J E Dowling
Dec 5, 1969·Science·M J Kushmerick, R J Podolsky
Oct 30, 1984·Biochemical and Biophysical Research Communications·A Ghalayini, R E Anderson
Jan 1, 1980·International Review of Cytology·E Holtzman, A M Mercurio
Apr 1, 1982·Journal of Neurocytology·A M Mercurio, E Holtzman
Nov 17, 1995·Science·M MeisterD A Baylor
Feb 1, 1995·Brain Research. Molecular Brain Research·D A ZachariasE E Strehler
Apr 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A HammesL Neyses
Jun 1, 1995·Cell Calcium·N F al-Baldawi, R F Abercrombie
Aug 1, 1996·Current Opinion in Neurobiology·R H Masland
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·H JiangD Wu
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·A ArnonB Minke
Sep 20, 1997·The Journal of Biological Chemistry·A G FiloteoJ T Penniston
Feb 19, 1998·Journal of Neurobiology·M SugiokaM Yamashita
Jun 2, 1998·Cell and Tissue Research·D Guerini
Jun 5, 1998·The American Journal of Physiology·M A Micci, B N Christensen
Apr 13, 2000·The European Journal of Neuroscience·M JuhaszovaE F Stanley
Aug 15, 2000·Microscopy Research and Technique·R GábrielE Veisenberger
Jan 12, 2001·Physiological Reviews·E E Strehler, D A Zacharias
Jan 12, 2001·Physiological Reviews·G L FainY Koutalos
Feb 27, 2001·The Journal of Comparative Neurology·D M SherryK M Standifer

❮ Previous
Next ❯

Citations

Oct 24, 2007·Molecular Neurobiology·Wallace B Thoreson
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Aug 5, 2005·Visual Neuroscience·René C RenteríaDavid Krizaj
Nov 8, 2007·Visual Neuroscience·Tamas Szikra, David Krizaj
Aug 15, 2012·The Journal of Physiology·Duco EndemanMaarten Kamermans
Nov 17, 2007·The European Journal of Neuroscience·Varda Shoshan-BarmatzNoga Vardi
Dec 22, 2005·The European Journal of Neuroscience·David Krizaj
Jul 11, 2008·The Journal of Comparative Neurology·Paul WitkovskyDavid Krizaj
Jul 20, 2005·Progress in Retinal and Eye Research·Ruth HeidelbergerPaul Witkovsky
Jun 22, 2005·Experimental Eye Research·David Krizaj
May 18, 2005·The International Journal of Biochemistry & Cell Biology·Varda Shoshan-BarmatzNoga Vardi
Jun 28, 2014·Frontiers in Cellular Neuroscience·Manuel Castellano-Muñoz, Anthony J Ricci
Jun 2, 2017·Physiological Reviews·Nicholas StaffordElizabeth J Cartwright

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Bioscience : a Journal and Virtual Library
D Krizaj, David Copenhagen
The International Journal of Biochemistry & Cell Biology
Varda Shoshan-BarmatzNoga Vardi
© 2022 Meta ULC. All rights reserved