Expression of carbohydrate antigens in the rat uterus during early pregnancy and after ovariectomy and steroid replacement

Journal of Reproduction and Fertility
S J KimberS R Glasser

Abstract

Monoclonal antibodies were used to examine the expression of a number of carbohydrate antigens in the rat endometrial epithelium from day 1 to day 8 of pregnancy and in ovariectomized rats supplemented with ovarian steroids. Carbohydrate antigens based on the Gal beta 1-GlcNAc backbone structure were expressed and some of these (Le(y), Le(x), B antigen) were present at all stages of pregnancy and independent of ovarian steroids. The H-type-2 antigen was stimulated by progesterone and expressed in the sensitized and receptive uterus, but was not detected after implantation or, in ovariectomized rats, in the refractory phase. The H-type-1 antigen, which is stimulated by oestrogen in the mouse, appeared to be stimulated by progesterone in rats. It was expressed throughout the period of pregnancy but maximal expression was found on days 4-5. The histo-blood group A antigen appeared in ovariectomized rats only after treatment with progesterone followed by three daily injections of progesterone and oestrogen, and in the corresponding postimplantation period of pregnant rats. Its appearance corresponded to the loss of detectable H-type-2 antigen. This study shows that the rat endometrial epithelium expresses some carbohydrate antigens...Continue Reading

Citations

Jan 13, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C R MurphyM B Thompson
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Anna P Ponnampalam, Peter A W Rogers
Jun 25, 2004·American Journal of Reproductive Immunology : AJRI·S WoldesenbetG R Newton
Jan 7, 2014·Differentiation; Research in Biological Diversity·Fuller W Bazer, Gregory A Johnson
Feb 12, 2015·Journal of Animal Science and Biotechnology·Greg A JohnsonFuller W Bazer
Sep 9, 2004·Cell Research·Christopher R Murphy
Jan 7, 2003·In Vitro Cellular & Developmental Biology. Animal·S WoldesenbetG R Newton
Jul 5, 2017·Experimental and Therapeutic Medicine·Juan GuYing Kong
Aug 22, 2017·Glycoconjugate Journal·Elham AliabadiFakhreddin Mesbah Ardekani
Jun 30, 2000·Seminars in Cell & Developmental Biology·S J Kimber, C Spanswick

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