PMID: 3384020May 1, 1988Paper

Expression of cartilage-matrix genes and localization of their translation products in the embryonic chick eye

Experimental Eye Research
P A Tsonis, P F Goetinck

Abstract

The presence of cartilage-matrix molecules in the embryonic chick eye was shown by means of measuring RNA expression and immunostaining studies. The molecules examined were proteoglycan core protein (PG-core), link protein (LP), cartilage-matrix protein (CMP) and type II collagen. The genes encoding these proteins are expressed in 8- to 11-day embryonic chick eyes at constant steady-state levels. Immunopositive stained tissues include sclera, choroid, cornea, lens capsule (PG-core, LP, CMP), lens epithelium, lens fibers (LP, CMP) and the membranes in the retina (LP). In addition, data from comparative studies employing the eyes from the proteoglycan core-protein-deficient mutant, nanomelia, indicate that levels of mRNA for core protein are almost absent and that CMP is reduced in the above-mentioned tissues.

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Citations

Mar 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S Mundlos, B Zabel
Aug 31, 2002·Molecular Reproduction and Development·Guang Wei SunToshihiko Terao
May 15, 1993·Experientia·P J Neame, F P Barry
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Jun 15, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·F DeákM Paulsson
Apr 25, 1991·Nucleic Acids Research·C RhodesY Yamada
Mar 15, 1996·European Journal of Biochemistry·A AszódiZ Bösze
Oct 18, 2012·Investigative Ophthalmology & Visual Science·Tiarnan D L KeenanPaul N Bishop
Jan 1, 1994·Progress in Histochemistry and Cytochemistry·S Mundlos
Oct 30, 2001·Osteoarthritis and Cartilage·D SegatN Smyth
Nov 9, 2016·Experimental Eye Research·Ying LiuDeepak P Edward
Jan 1, 2011·Cartilage·Eunmee HongDominik R Haudenschild

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