Expression of caveolin-3 immunoreactivities in the developing sciatic nerve of the rat

Muscle & Nerve
Ho J LeeBum S Kwon

Abstract

Caveolae are formed by the caveolin (CAV) family of proteins, CAV-1, -2, and -3. CAV-1 and -2 are co expressed in many cell types, whereas CAV-3 is muscle-specific and mutation of the CAV-3 gene causes muscular dystrophy. CAV-3 has also been detected in brain astroglial cells and in peripheral nerves along with CAV-1. Therefore, we sought to determine whether CAV-3 protein is expressed in developing peripheral nerves by using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). We found that CAV-3 immunoreactivities (IRs) were Localized in the myelin sheath during peripheral nerve development. CAV-3 IRs were intense during the early postnatal stage, but decreased as the peripheral nerves matured at postnatal weeks 3-5. CAV-3 mRNA expression was also markedly decreased during postnatal development. Because the expression pattern of CAV-3 IRs was opposite that of CAV-1 IRs. CAV-1 and -3 might be involved in different phases of peripheral nerve myelination and play complementary roles in myelin maturation and peripheral nerve development.

References

Aug 1, 1990·Brain Research. Molecular Brain Research·N StahlB Popko
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·M SargiacomoM P Lisanti
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J KoleskeM P Lisanti
Dec 1, 1994·The Journal of Cell Biology·P E SchererH F Lodish
Jun 27, 1997·The Journal of Biological Chemistry·J A EngelmanM P Lisanti
Feb 25, 1999·Biochemistry·C J FieldingP E Fielding
Jul 13, 1999·Glia·D D MikolE L Feldman
Dec 15, 2000·Human Molecular Genetics·Y HagiwaraT Kikuchi
May 23, 2001·Molecular and Cellular Endocrinology·J I KawabeY Ishikawa
Apr 23, 2003·Biochemical and Biophysical Research Communications·Donald D DoyleH Clive Palfrey
Sep 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W I SilvaI K Salgado-Villanueva

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Citations

Jul 9, 2009·European Journal of Human Genetics : EJHG·Elisabetta GazzerroCarlo Minetti
Mar 26, 2014·Journal of Anatomy·Kevin PeikertChristian Albrecht May

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