Expression of CD133 in differentiated thyroid cancer of young patients

Journal of Clinical Pathology
Myriam Decaussin-Petruccigroup of Pathologists of the Rhône Alpes Region

Abstract

CD133 expression in cancer is frequently associated with poor outcome. Thyroid carcinomas are rare in childhood and adolescence and are associated with a higher risk of recurrence and more metastases than the adult tumours. The aim of the study was to assess whether the expression of CD133 in thyroid carcinomas of children, adolescents and young adults was correlated with clinical prognostic factors. Tissue microarrays were constructed with 235 tumours coming from 208 young adults with a median age of 28 years and 27 children with a median age of 13 years. An immunohistochemical study was performed with anti-CD133 antibody. CD133 expression was evaluated, using a semiquantitative score based on the percentage of positive cells. The mutation status of tumours was evaluated by reverse transcriptase PCR. Three cell lines were used to confirm CD133 expression by western blot. CD133 expression was found in 43% of adult and 37% of child tumours and was confirmed by western blot in cell lines. In young adults, the expression of CD133 was significantly more frequent in patients with tumours >3 cm (p=0.04) and in patients with lymph node metastases (p=0.02). The expression of CD133 was more frequent in patients in whom the tumour presen...Continue Reading

References

Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·B EstourH Klandorf
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M SchlumbergerM Tubiana
Nov 2, 2001·Nature·T ReyaI L Weissman
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Atsushi KumagaiShunichi Yamashita
May 7, 2005·Thyroid : Official Journal of the American Thyroid Association·Karen PenkoGary Francis
Nov 24, 2006·Nature·Lucia Ricci-VitianiRuggero De Maria
Feb 27, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elena MonzaniCaterina A M La Porta
Jun 16, 2007·Gastroenterology·Stephanie MaXin-Yuan Guan
Dec 11, 2007·The Journal of Pathology·D MizrakM R Alison
Mar 4, 2008·Endocrine-related Cancer·Dolly ThomasReigh-Yi Lin
Jul 28, 2009·The Journal of Surgical Research·Anthony R HoganJuan E Sola
Nov 10, 2009·The Journal of Clinical Endocrinology and Metabolism·Wen ZhuGilbert J Cote
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Thomas KlonischSabine Hombach-Klonisch
Oct 21, 2010·Cancer Research·Matilde TodaroGiorgio Stassi
Jul 23, 2011·The Journal of Clinical Endocrinology and Metabolism·Terry F DaviesRisheng Ma
Oct 27, 2011·The Journal of Endocrinology·Alessandra Fierabracci
Dec 14, 2011·Thyroid : Official Journal of the American Thyroid Association·Geneviève SassolasAlfredo Fusco
Apr 25, 2012·Human Cell·Rosario Gil-BensoConcha López-Ginés
Aug 4, 2012·Nature·Monya Baker
Apr 6, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kousuke HashimotoKazuo Shirouzu
Nov 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G G SunW N Hu
Jun 13, 2014·International Journal of Cancer. Journal International Du Cancer·Colleen WebberPatti A Groome
Jun 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weimin WangJianwei Zhou

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