PMID: 10516610Oct 12, 1999

Expression of CD134 (0X-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease

Cytometry
L S LambA P Gee

Abstract

CD134 (OX-40) is an activation-associated antigen which functions as a costimulatory receptor for CD4+ T cells. In order to determine the expression of CD134 during immune recovery following allogeneic bone marrow transplantation (BMT), we measured its expression on T cells and T cell subsets during the first 100 days following BMT in 26 patients. CD4+CD134+ T could be seen approximately 14 days following BMT cells in patients who did not develop GvHD which required therapy (n = 20). The percentage of CD4+CD134+ cells continued to increase up to the fourth week following BMT to a maximum of 40-50% of CD4+ T cells (normal = 1-8%). Two patients who developed Grade I-II GvHD and who responded to treatment with pulsed high-dose methylprednisolone (MPD) showed a decline of approximately 40% in CD4+CD134+ T cells was seen within 48 hours of treatment. Four patients who developed GvHD that was not responsive to MPD and who later developed high IV GvHD showed increasing CD4+CD134+ T cells up to 85% of the CD4+ T cells. Additionally, rapid increases in CD134+ T cells following antibody-based T cell therapy were associated with GvHD recurrence. In no cases was the percentage of CD134+ CD4+ T cells predictive of clinical GvHD. In this exp...Continue Reading

References

Jun 3, 2004·Nature Reviews. Immunology·Kazuo SugamuraAndrew D Weinberg
Jun 24, 2006·Clinical and Experimental Immunology·M Paz MoranteS Vidal
Apr 6, 2005·Transplantation Proceedings·Y MiuraA D Hess
Jan 1, 1999·Cytotherapy·A P Gee
Apr 28, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Philip R StreeterRichard T Maziarz
Dec 20, 2019·Journal of Virology·Bochao WangYasuko Mori

Citations

Jan 26, 1989·The New England Journal of Medicine·C AnasettiE M Mickelson
Sep 26, 1985·The New England Journal of Medicine·P G BeattyR Storb
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·K De BosscherG Haegeman

Related Concepts

Flow Cytometry
T-Lymphocyte
CD4 Antigens
TNFRSF4
OX40 Receptors
Tumor Necrosis Factor Receptor
Graft-vs-Host Disease
Bone Marrow
Recurrent Malignant Neoplasm
TNFRSF4 wt Allele

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