PMID: 9184633Jun 1, 1997Paper

Expression of CD23 in the germinal center of thymus from myasthenia gravis patients

Journal of Neuroimmunology
Hiroyuki MuraiT Watanabe

Abstract

In order to investigate a pathogenic role of germinal centers which appear in the hyperplastic thymus of myasthenia gravis (MG) patients, we performed an immunohistochemical study using various monoclonal antibodies including CD23. In contrast with tonsilar germinal centers from non-MG individuals, CD23 was strongly and diffusely expressed in the whole area of germinal centers of MG thymi, including the outer zone. In addition, we measured the serum level of soluble CD23 (sCD23) in MG patients at various clinical stages. The high serum sCD23 levels, which were noted in the unthymectomized patients, fell to within normal range over 5 years after thymectomy, and the decline of serum sCD23 correlated well with clinical improvement. CD23 is thought to be responsible for preventing unselected germinal center B cells from entering apoptosis and, in turn, leads to the survival of auto-reactive B cell clones.

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Citations

Jul 6, 2001·Scandinavian Journal of Immunology·N Amft, S J Bowman
Jan 25, 2003·Annals of the New York Academy of Sciences·Waldemar L Olszewski
Mar 30, 2013·Autoimmunity Reviews·Sonia Berrih-AkninRobert P Lisak
Jan 12, 2012·Autoimmune Diseases·Samia Ragheb, Robert P Lisak
Sep 18, 2014·Journal of Neuroimmunology·Jeng-Dau TsaiChang-Ching Wei
Nov 23, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wataru IshiiShu-Ichi Ikeda
Oct 7, 2004·Journal of the Neurological Sciences·Hiroyuki MuraiJun-Ichi Kira
Aug 30, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter SzodorayMichael Centola
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Mar 22, 2006·Nature Immunology·Danielle L DraytonNancy H Ruddle
Feb 5, 2005·Arthritis and Rheumatism·Biao ZhengShuhua Han

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