Expression of CD23/CD21 and CD40/CD40 ligand in vernal keratoconjunctivitis

Eye
A M Abu El-AsrarK Geboes

Abstract

The overproduction of immunoglobulin E (IgE) antibodies is associated with vernal keratoconjunctivitis (VKC). CD23/CD21 and CD40/CD40 ligand (CD40L) interactions have been proposed to be involved in the regulation of IgE synthesis. The purpose of the present study was to investigate the presence and distribution of CD23, CD21, CD40 and CD40L in the conjunctiva from patients with active VKC. Conjunctival biopsy specimens from 8 subjects with active VKC and 6 control subjects were studied. We used immunohistochemical techniques and a panel of monoclonal antibodies (mAbs) directed against CD23, CD21, CD40 and CD40L. In addition, a panel of mAbs were used to characterise the composition of the inflammatory infiltrate. In the normal conjunctiva, basal epithelial cells and vascular endothelial cells in the upper substantia propria showed a constitutive very weak immunoreactivity for CD40. The immunoreactivity for CD23, CD21 and CD40L was absent. In VKC specimens, the stromal inflammatory infiltrate was orgnanised as a diffuse infiltrate and as small lymphoid follicles consisting of CD20+ B lymphocytes intermingled with smaller numbers of CD3+ T lymphocytes, and CD68+ monocytes/macrophages. Lymphocytes in the centre of the lymphoid fo...Continue Reading

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Citations

Jun 8, 2002·Progress in Retinal and Eye Research·Andrea Leonardi
Jan 25, 2003·International Ophthalmology Clinics·Khalid F Tabbara
Jan 25, 2003·International Ophthalmology Clinics·Ahmed M Abu El-AsrarKarel Geboes
Jan 25, 2003·International Ophthalmology Clinics·Andrea Leonardi, Antonio G Secchi
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Stefan D Trocme, Karan K Sra
Sep 18, 2007·Current Opinion in Allergy and Clinical Immunology·Andrea LeonardiLaura Motterle
May 18, 2006·Acta Ophthalmologica Scandinavica·Andrea LeonardiAntonio G Secchi
Sep 13, 2008·Acta Ophthalmologica·Sunil Kumar
Aug 4, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Andrea LeonardiMario Plebani

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