PMID: 19123977Jan 7, 2009Paper

Expression of CD320 in human B cells in addition to follicular dendritic cells

BMB Reports
Whajung ChoJ Choe

Abstract

CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. Although CD320 is known to enhance proliferation of germinal center (GC) B cells, little other information is available. In this study, we investigated its cellular distribution in the GC. Confocal microscopy of human tonsil sections revealed co-localization of CD320 with CD19 and CD38 but not with CD3 indicating that GC B cells expressed CD320 in addition to FDC. In purified GC B cells, CD320 expression was inhibited in the nucleus, membrane and cytoplasm. Reverse transcriptase-polymerase chain reaction confirmed CD320 mRNA expression in B cells. These finding indicate that CD320 is expressed in B cells in addition to FDC, and that its GC activity may be more complicated than previously thought.

References

Dec 1, 1991·Trends in Biochemical Sciences·C Dingwall, R A Laskey
Sep 6, 1991·Cell·D CosgroveD Mathis
Jul 1, 1984·The American Journal of Anatomy·P Nieuwenhuis, D Opstelten
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Jan 6, 1997·The Journal of Experimental Medicine·Y J LiuK W Moore

❮ Previous
Next ❯

Citations

May 2, 2012·Nature Reviews. Gastroenterology & Hepatology·Marianne J NielsenSøren K Moestrup
Jan 29, 2021·Journal of Virology·Veronika KrchlíkováDaniel Elleder

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.