Expression of CD44 adhesion molecules on human placentae

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Chel Hun ChoiDuk-Soo Bae

Abstract

This study was performed to characterize CD44 expression in human placentae. We conducted reverse transcriptase polymerase chain reaction (RT-PCR) analyses of CD44H (hematopoietic form, also called CD44s) and CD44R1 (epithelial form) in 14 normal term placentae, and immunohistochemical analysis of CD44H and CD44v6 in 31 placentae (25 term and 6 first-trimester). All 14 term placentae expressed CD44H (double bands) suggesting expression of alternative isoforms on the placentae. CD44R1 was expressed on 3 of 14 (21.4%) term placentae. Immunohistochemical analysis revealed expression of CD44H in all the placentae examined. However, positive staining for CD44v6 was observed in 3 of 6 (50%) first-trimester and only 6 of 25 (24%) term placentae showing decreased expression on term placentae. Positive staining for CD44v6 was observed on the trophoblast surface of immature villi especially in the sub-chorionic area where hypoxic conditions prevail. These results suggest that CD44 splicing variants might play a role in the invasion of trophoblast into maternal tissue in early pregnancy.

References

Aug 1, 1992·The Journal of Cell Biology·L ThomasI Stamenkovic
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Jan 31, 1992·Biochemical and Biophysical Research Communications·D L CooperN R Isola
May 1, 1991·The Journal of Clinical Investigation·S JalkanenP Klemi
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Oct 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·R Ohlsson
Jul 1, 1987·Placenta·E D Adamson
Jan 1, 1994·The Journal of Cell Biology·C R MackayU Günthert
Jul 1, 1993·The Journal of Cell Biology·R J PeachA Aruffo
Jan 1, 1993·Advances in Immunology·J LesleyP W Kincade
Sep 17, 1998·The Journal of Clinical Investigation·P EstessM H Siegelman
Aug 22, 2001·European Journal of Histochemistry : EJH·D MarzioniM Castellucci
May 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J.-H. LeeK.-B. Park
Apr 19, 2002·Zeitschrift für Gastroenterologie·B JünglingA Stallmach

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Citations

Mar 31, 2010·American Journal of Obstetrics and Gynecology·Yevgeniya PozharnyMen-Jean Lee
Aug 25, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Safaa A ElsalamMohamed A Alabiad

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