PMID: 8947066Nov 1, 1996Paper

Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects

The European Respiratory Journal
D G PeroniS T Holgate

Abstract

We have investigated the expression of cell surface markers and leucocyte cell adhesion molecules by immunohistochemistry in bronchial biopsies from 10 mild atopic asthmatics and 8 normal, nonatopic subjects. Significantly increased numbers of eosinophils (p<0.01) were evident in the bronchial submucosa of asthmatic subjects. In epithelium there were more CD44+ (p<0.02) and lymphocyte function-associated antigen-1 (LFA-1)+ (p<0.06) leucocytes in asthmatics than in normal subjects. Bronchial epithelial cells stained positively with anti-CD44 monoclonal antibodies (moAb) in both groups; however, when the staining was expressed as percentage of the total basement membrane, a considerable and highly significant increase was observed in the asthmatics (median 80 vs 22%, p=0.003). Few leucocytes were positive for very late activation antigen (VLA)-1, VLA-2 and VLA-4. The moAb for VLA-6 stained the basement membrane of the bronchial epithelium; while intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were constitutively expressed in endothelium. A positive correlation was found between LFA-1+ cells and activated eosinophils (EG2+) in the submucosa (p<0.005; r(s)=0.80). We conclude that even in mi...Continue Reading

Citations

Oct 11, 2012·The Journal of Biological Chemistry·Rosanna Malbran FortezaMaria E Monzon
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Pilar MartínFrancisco Sánchez-Madrid
May 24, 2011·Pulmonary Pharmacology & Therapeutics·James G Martin, Mauro Novali
Mar 9, 2011·International Immunopharmacology·Manar A Nader
Sep 25, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·U NihlénC G Löfdahl
Aug 23, 2019·International Journal of Molecular Sciences·Xiner NieBo Li
Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S H LeirP M Lackie
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shih-Hsing LeirPeter M Lackie
Jul 25, 2000·Clinics in Chest Medicine·R J Homer, J A Elias

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