Expression of CD56 in patients with adenomyosis and its correlation with dysmenorrhea

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Fei WangChangzhong Li

Abstract

To investigate the expression of CD56 in endometrial samples from patients with adenomyosis and its relationship with menstrual cycle phase and severity of dysmenorrhea. 40 patients with histologically proved adenomyosis (proliferative n=20; secretory n=20) and dysmenorrhea were examined in this study, control groups includes 20 patients with adenomyosis without dysmenorrhea (main complaint: menorrhagia) and 20 patients without adenomyosis who had undergone hysterectomy for non-endometrial pathology (no dysmenorrhea medical history). Immunohistochemical staining against CD56 was performed for the eutopic and ectopic endometrium from patients with adenomyosis and the control samples. The expression of CD56 was determined by calculating the H-score and the severity of dysmenorrhea was determined using the visual analogue scale. The menstrual cycle status and the disease severity were compared to the levels of staining. CD56 was expressed mainly in the endometrial glandular epithelium in patients with adenomyosis and normal endometrium. The epithelial staining intensity of CD56 in ectopic lesions of adenomyosis with dysmenorrhea was obviously higher than in the corresponding eutopic endometrium and control groups (P<0.01). There w...Continue Reading

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Citations

Aug 28, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J BhullarD K Hapangama
Oct 9, 2020·Seminars in Reproductive Medicine·Junyu ZhaiLinda C Giudice
Apr 24, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Qing LiKe-Qin Hua

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