Expression of CD68+ tumor-associated macrophages in patients with diffuse large B-cell lymphoma and its relation to prognosis

Pathology International
Sverker HasselblomPer-Ola Andersson

Abstract

Tumor-associated macrophages (TAM) have been ascribed both pro- and anti-tumor properties, but the majority of clinical cancer studies have shown that the presence of a high number of TAM is related to poor prognosis, suggesting that TAM predominantly exert pro-tumoral activity. The prognostic role of TAM in patients with diffuse large B-cell lymphoma (DLBCL), however, is so far unknown. Therefore, TAM were immunohistochemically stained with a CD68 antibody in a retrospective, population-based study including 176 DLBCL patients treated with curative intent. With the exception that patients >60 years of age had a larger number of CD68+ cells (1143 vs 1018 cells/mm2; P = 0.05), no significant differences were found between the number of CD68+ cells and other clinical factors. Similarly, germinal center B-cell (GCB)/non-GCB immunophenotype or low/high Ki-67 percentage were not associated with CD68 expression. Finally, no significant correlation was found between the number of CD68+ cells and progression-free survival (P = 0.34) or overall survival (P = 0.94). These data indicate that the pro-tumor effect of TAM has limited clinical relevance in DLBCL patients, which could imply that therapeutic strategies aimed at enhancing their ...Continue Reading

References

Jun 18, 2002·Seminars in Oncology·Kristoffer Hellstrand
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Sep 13, 2006·Cancer Metastasis Reviews·Alberto MantovaniAntonio Sica
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Minna TaskinenSirpa Leppä
Dec 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danielle CanioniLuc Xerri

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Citations

May 20, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maurice ReimannSoyoung Lee
Jan 22, 2013·Annals of Hematology·Elif SuyanıRauf Haznedar
Jul 31, 2013·Immunobiology·Maria Rosaria GaldieroSébastien Jaillon
Jan 1, 2010·Journal of Leukocyte Biology·Leanne C Huysentruyt, Michael S McGrath
Nov 23, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiro KomoharaMotohiro Takeya
Jun 12, 2012·Leukemia & Lymphoma·Jan Delabie
Feb 26, 2013·Leukemia & Lymphoma·Fotis AsimakopoulosPeiman Hematti
Feb 5, 2016·Journal of Cellular and Molecular Medicine·Qing-Hua ShuWei-Dong Jia
Dec 22, 2010·American Journal of Clinical Pathology·Paul N MeyerDennis D Weisenburger
Apr 24, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Deise Souza Vilas BôasJean Nunes dos Santos
Aug 22, 2013·British Journal of Haematology·Luis F PorrataSvetomir N Markovic
Jul 3, 2013·British Journal of Haematology·Kathrin Aprile von HohenstaufenEmanuele Zucca
Jan 4, 2012·Histopathology·Naoki WadaUNKNOWN Osaka Lymphoma Study Group
Oct 16, 2012·Journal of Cellular Physiology·Maria R GaldieroAlberto Mantovani
Feb 25, 2015·Pathology International·Yoshihiro KomoharaMotohiro Takeya
Jul 23, 2016·Pathology International·Motohiro Takeya, Yoshihiro Komohara
Jun 16, 2009·Medicinal Research Reviews·Marek Jakobisiak, Jakub Golab
Apr 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Shuang YuHaipeng Xiao
Mar 13, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·T MiyagakiS Sato
Aug 15, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Eri MatsukiJulie Teruya-Feldstein
Jun 6, 2018·Frontiers in Oncology·Lan V PhamRichard J Ford
Jan 15, 2020·Analytical Cellular Pathology (Amsterdam)·Alexandra Ioana CioroianuFlorica Staniceanu
Jan 11, 2020·Cancer Immunology, Immunotherapy : CII·Mikael RousselJonathan M Irish
Jul 10, 2017·Cancer Immunology, Immunotherapy : CII·Mikael RousselThierry Fest
Aug 17, 2019·Clinical & Translational Immunology·Osamu NoyoriShinya Suzu
Apr 17, 2020·Frontiers in Oncology·Giuseppina OpintoSabino Ciavarella
Aug 1, 2020·Journal of Clinical Medicine·Roberto TammaDomenico Ribatti
May 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J AndorskyJohn M Timmerman
Jan 21, 2021·Frontiers in Oncology·Fangzhen LinDongsheng Xiong

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