PMID: 9546609Apr 18, 1998Paper

Expression of C/EBP alpha, beta and delta in fetal and postnatal subcutaneous adipose tissue

Molecular and Cellular Biochemistry
K LeeR G Dean

Abstract

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors (C/EBP alpha, beta, and delta) has been implicated in the development and the metabolic regulation of adipocytes from in vitro studies, yet the function of these factors, particularly CEBP beta and delta, in vivo has not been characterized. To assess the role of these factors in vivo, subcutaneous adipose, tissue from fetal and postnatal pigs was examined for C/EBP alpha, beta, and delta expression in developing and mature adipocytes. Western blot analysis of fetal adipose tissue showed a progressive increase of C/EBP alpha expression in 50, 75 and 95 day old fetuses. C/EBP beta and delta proteins were not observed in fetal adipose tissue. These results were confirmed with immunohistochemical studies of fetal adipose showing enhanced C/EBP alpha expression in the nuclei of adipocytes and cells closely associated with adipose cell clusters from 75 and 95 day old fetuses. For the same tissues only light background staining with no differential enhancement was found for C/EBP beta and delta. In postnatal adipose tissue C/EBP alpha and C/EBP beta protein were expressed in both 8 day old postnatal and mature (180 day) pigs. C/EBP delta reactive products were ...Continue Reading

Citations

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D B HausmanR J Martin
Dec 8, 2004·Journal of Animal Science·T D Brandebourg, C Y Hu
Jan 7, 2003·In Vitro Cellular & Developmental Biology. Animal·Shih-Torng DingHarry J Mersmann
Sep 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mireille RaccurtClaude Duchamp
Aug 16, 2005·Journal of Animal Science·T D Brandebourg, C Y Hu
Mar 21, 2007·Journal of Cellular Biochemistry·Donna M Sosnoski, Carol V Gay
Sep 28, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R L McNeelH J Mersmann
Sep 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S T DingH J Mersmann

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