Expression of cell adhesion molecules by endothelium in the human lower uterine segment during parturition at term

American Journal of Obstetrics and Gynecology
M WinklerW Rath

Abstract

Our purpose was to determine whether the expression of certain adhesion molecules by endothelium in the human lower uterine segment at term varies with the degree of cervical dilatation. Biopsy specimens of the lower uterine segment of 34 women undergoing cesarean section at term at various stages of cervical dilatation were immunostained for endothelial leukocyte adhesion molecule-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and platelet-endothelial cell adhesion molecule. The expression of endothelial leukocyte adhesion molecule-1 was significantly greater at more than 6 cm dilatation than at less than 2 cm (p = 0.00031) as was that of vascular cell adhesion molecule-1 (p = 0.033). Expression of intercellular adhesion molecule-1 and platelet-endothelial cell adhesion molecule did not vary with the degree of cervical dilatation. Cervical dilatation is associated with up-regulation of certain endothelial cell adhesion molecules. The findings support the hypothesis that certain processes associated with cervical dilatation at term resemble those involved in the acute inflammatory reaction.

References

May 1, 1992·American Journal of Obstetrics and Gynecology·R OsmersW Kuhn
Mar 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M A Jutila
Apr 1, 1992·American Journal of Reproductive Immunology : AJRI·R RomeroC A Dinarello
Jan 1, 1990·Archives of Gynecology and Obstetrics·R OsmersW Kuhn
Apr 1, 1990·Immunological Reviews·T M Carlos, J M Harlan
Oct 1, 1988·American Journal of Obstetrics and Gynecology·M R RajabiJ F Woessner
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Aug 1, 1993·American Journal of Obstetrics and Gynecology·S L OpsjłnR Austgulen
May 1, 1993·American Journal of Obstetrics and Gynecology·T Rechberger, J F Woessner

❮ Previous
Next ❯

Citations

May 27, 1999·Journal of Perinatal Medicine·M Winkler, W Rath
Nov 22, 2008·Journal of Perinatal Medicine·Birgit KempWerner Rath
Sep 5, 2006·American Journal of Obstetrics and Gynecology·Chong Jai KimRoberto Romero
Jan 22, 2010·Biology of Reproduction·Nardhy Gomez-LopezFelipe Vadillo-Ortega
Nov 20, 2004·American Journal of Reproductive Immunology : AJRI·Patrizia LuppiJulie A Deloia
May 4, 1999·Journal of Perinatal Medicine·W RathB Kemp
Sep 17, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oksana ShynlovaStephen J Lye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.