Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors

Clinical and Experimental Medicine
Alexandra Papoudou-BaiPanagiotis Kanavaros

Abstract

The human thymus supports the production of self-tolerant T cells with competent and regulatory functions. Various cellular components of the thymic microenvironment such as thymic epithelial cells (TEC) and dendritic cells play essential roles in thymic T cell differentiation. The multiple cellular events occurring during thymic T cell and TEC differentiation involve proteins regulating cell cycle and apoptosis. Dysregulation of the cell cycle and apoptosis networks is involved in the pathogenesis of thymic epithelial tumors (TET) which are divided into two broad categories, thymomas and thymic carcinomas. The present review focuses on the usefulness of the analysis of the expression patterns of major cell cycle and apoptosis regulators in order to gain insight in the histophysiology of thymus and the histopathology, the clinical behavior and the biology of TET.

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Citations

Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Alexandra BarboutiPanagiotis Kanavaros
Sep 8, 2016·Clinical and Experimental Medicine·Alexandra Papoudou-BaiPanagiotis Kanavaros

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