Abstract
The objective of this study was to evaluate the expression patterns of cell cycle-associated proteins in newly diagnosed non-muscle-invasive bladder cancer (NMIBC) to clarify the significance of these proteins as prognostic predictors in 161 consecutive patients undergoing transurethral resection (TUR). Expression levels of 7 cell cycle-associated proteins, including Aurora-A, c-erbB2, cyclin-D1, Ki-67, p21, p27, and p53, in TUR specimens were measured by immunohistochemical staining. Of the 7 proteins, weak expression of p21 was significantly associated with the incidence of intravesical recurrence (P = 0.012). Univariate analysis identified expression level of p21, tumor size, T stage, and concomitant carcinoma in situ (CIS) as significant predictors for intravesical recurrence (P = 0.0053, 0.0014, 0.024, and 0.035, respectively). Of these, p21 expression, tumor size, and concomitant CIS appeared to be independently related to intravesical recurrence (P = 0.029, 0.025, and 0.016, respectively). Furthermore, there were significant differences in intravesical recurrence-free survival according to positive patterns of these 3 independent factors; that is, intravesical recurrence occurred in 17 of 72 patients who were negative fo...Continue Reading
References
Dec 22, 1999·The Journal of Urology·F Millán-RodríguezJ Vicente-Rodríguez
Aug 23, 2000·The Journal of Urology·F Millán-RodríguezJ Vicente-Rodríguez
Dec 18, 2001·Urology·T HisatakiT Tsukamoto
Jan 18, 2002·Urology·Hideaki MiyakeIsao Hara
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Alessandro SgambatoGian Paolo Trentini
Feb 1, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L L SantosC S Lopes
Apr 4, 2003·International Journal of Cancer. Journal International Du Cancer·Lúcio SantosCarlos Lopes
Jun 20, 2003·European Urology·F MayH Schwaibold
Aug 22, 2003·BJU International·B Ali-El-DeinM A Ghoneim
Oct 9, 2004·International Journal of Cancer. Journal International Du Cancer·Tobias ZellwegerLukas Bubendorf
Nov 20, 2004·Urological Research·Stephen G Williams, John P Stein
Mar 1, 2005·Cancer Research·Antonio Garcia-EspañaAngel Pellicer
May 19, 2005·Cancer Research·Andrei L Gartel, Senthil K Radhakrishnan
Aug 16, 2005·Urology·Takahiro InoueOsamu Ogawa
Mar 7, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P Mhawech-FaucegliaF R Herrmann
Nov 7, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Iori SakaiMasato Fujisawa
Feb 14, 2007·The Journal of Urology·Young Deuk ChoiWon Jae Yang
Mar 14, 2007·Urologic Oncology·Toshifumi KurahashiMasato Fujisawa
Jul 25, 2007·BJU International·Paulette Mhawech-FaucegliaFrançois R Herrmann
Citations
Mar 8, 2014·World Journal of Surgical Oncology·Baoming RenSongdi Wu
Sep 13, 2013·Der Urologe. Ausg. A·M BöhmUNKNOWN Arbeitskreis Urinzytologie der DGU (Deutsche Gesellschaft für Urologie)
Feb 23, 2012·Current Urology Reports·Michael RinkShahrokh F Shariat
Sep 13, 2014·International Journal of Molecular Sciences·Wojciech JóźwickiJerzy Siekiera
Oct 23, 2012·European Urology·Ashish M KamatUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Dec 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chenghe WangZhangqun Ye
Apr 29, 2015·BioMed Research International·Chenghe WangZhangqun Ye
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Apr 23, 2015·Japanese Journal of Clinical Oncology·Jiao ZhangHaitao Wang
Mar 13, 2014·Urologic Oncology·Malte BöhmOliver W Hakenberg
Sep 30, 2014·Urologic Oncology·Bing LiuMasato Fujisawa
Nov 12, 2014·International Urology and Nephrology·Junjie ZhaoChuanliang Xu
Jul 15, 2016·PloS One·Yuejun TianZhiping Wang
Aug 9, 2016·Medicine·Hisashi OshiroAshish M Kamat
Jan 24, 2018·Expert Review of Anticancer Therapy·Oner Sanli, Yair Lotan
May 17, 2012·British Journal of Cancer·Y KususdaM Fujisawa
Nov 18, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Alana D RanziClaudia G Bica
Dec 17, 2017·Oncotarget·Kyungtae KoJa Hyeon Ku
Apr 16, 2016·Medicine·Yihuan LuoGang Chen
Feb 11, 2015·Advances in Anatomic Pathology·James P Solomon, Donna E Hansel
Oct 9, 2014·Oncology Letters·Elżbieta PłuciennikAndrzej K Bednarek