Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over-expression of cyclin E and p53, reduction of p21(WAF1/CIP1) and dysregulation of cyclin D1 and p27(KIP1)

Histopathology
M OhbuI Okayasu

Abstract

Cell cycle regulatory proteins were analysed by immunohistochemistry in order to clarify how their expression changes with the degree of atypia as oesophageal surface squamous epithelium progresses from normal mucosa, through reactive change, low-grade dysplasia, and high-grade dysplasia to mucosal invasive carcinoma. Immunostaining for cyclin D1, cyclin E, p21, p27, p53 and Ki67 proteins was performed using 22 normal mucosa, 17 reactive change, 22 low-grade dysplasia, 15 high-grade dysplasia and 22 mucosal invasive carcinoma specimens. Normal mucosa, low-grade dysplasia and high-grade dysplasia samples were taken from patients without any oesophageal invasive carcinoma by endoscopic biopsy or endoscopic mucosal resection, and reactive change and mucosal invasive carcinoma were obtained from oesophagectomy material. Stepwise over-expression of cyclin E (P < 0.0001) and p53 (P < 0.0001), reduction of p21 (P=0.0189) and dysregulation of cyclin D1 and p27 were observed in the multistep process of oesophageal carcinogenesis. Significant differences in expression of p27 (P < 0.0001), p53 (P=0.0299) and Ki67 (P=0.0101) were observed between reactive change and low-grade dysplasia. Furthermore, expression of cyclin D1, cyclin E, p27 a...Continue Reading

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Citations

Sep 19, 2007·International Journal of Hematology·Jean-Marie PeloponeseKuan-Teh Jeang
May 31, 2008·Digestive Diseases and Sciences·Jorge-Shmuel DelgadoMarc Bissonnette
Aug 11, 2015·Critical Reviews in Oncology/hematology·Priyanka Sharma, Rinu Sharma
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Oct 18, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Khaldoun AlmhannaDomenico Coppola
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Apr 24, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marcelo BinatoMaria Isabel Edelweiss
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Nov 8, 2003·World Journal of Gastroenterology : WJG·Lian-Fu ZuoJiang-Hui Liu

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