Expression of cellular prion protein (PrP(c)) in schizophrenia, bipolar disorder, and depression

Journal of Neural Transmission
Serge WeisIda C Llenos

Abstract

Cellular prion protein (PrP(c)) is a copper-binding, membrane-attached GPI-anchored glycoprotein characterized by a high degree of amino acid sequence conservation among mammals. PrP(c) expression has been demonstrated in neurons, microglia, lymphocytes, and keratinocytes. Recently, the concept that PrP(c) may be involved in the defense against oxidative stress was advanced. In the present study, we used immunohistochemistry for PrP(c) to investigate 60 brains from the Stanley Neuropathology Consortium (15 controls, 15 patients with schizophrenia, 15 with bipolar disorder, and 15 with major depression). Rating scores as well as the numerical density of PrP(c)-positive and -negative neurons and glial cells were determined in the cingulate gyrus. All four groups showed a very high interindividual variation. PrP(c)-positive glial cells were significantly reduced in the white matter of patients with schizophrenia, bipolar disorder, and major depression. A similar result was obtained for the white matter in bipolar patients using rating scales. From the confounding variables, use of medication (i.e. antipsychotics, antidepressants, and mood stabilizers) had a significant effect on the expression of PrP(c) by neurons and glial cells....Continue Reading

References

Apr 20, 1992·The Science of the Total Environment·T BarrettC J Bostock
Mar 1, 1988·The Journal of General Virology·B CaugheyB Chesebro
Oct 1, 1986·Journal of Neuroscience Methods·H Haug
Aug 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R D Reddy, J K Yao
Aug 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S P Mahadik, R E Scheffer
Jan 1, 1997·Free Radical Biology & Medicine·Y J SuzukiA Sevanian
Jun 19, 1998·Neuroreport·D R BrownH A Kretzschmar
Jun 26, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D R BrownH A Kretzschmar
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Dec 5, 1998·The Journal of Biological Chemistry·P C Pauly, D A Harris
Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·S E ArnoldP Parchi
Oct 3, 1999·Neuroscience Letters·S Verghese-NikolakakiT Sklaviadis
Nov 5, 1999·The Biochemical Journal·D R BrownI M Jones
Mar 10, 2000·FEBS Letters·T SimonicS Ronchi
Feb 13, 2001·Trends in Neurosciences·D R Brown
Feb 24, 2001·Acta Neuropathologica·I FerrerT Ribalta
May 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S P MahadikH Lal
Nov 22, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P Mastrangelo, D Westaway
Nov 24, 2001·FEBS Letters·B StrumboT Simonic
Feb 20, 2002·FEBS Letters·Vilma R MartinsRicardo R Brentani
Aug 15, 2002·Neurochemistry International·Vilma Regina Martins, Ricardo Renzo Brentani
Jan 28, 2003·Trends in Genetics : TIG·Eric Rivera-MillaEdward Málaga-Trillo
Dec 17, 2003·Journal of Neurochemistry·Kenneth L MoyaLuigi Di Giamberardino
Jan 28, 2004·Cell·Adriano Aguzzi, Magdalini Polymenidou
Feb 6, 2004·Journal of Neurochemistry·Marco A M PradoRicardo Renzo Brentani
Mar 10, 2004·International Review of Neurobiology·Jeffrey K Yao, Daniel P van Kammen
Apr 2, 2004·Neurobiology of Disease·David R Brown
Sep 8, 2004·Journal of Neuroscience Research·Brett Langley, Rajiv R Ratan
Oct 21, 2004·Nature Reviews. Microbiology·Charles Weissmann
Jan 13, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xavier Roucou, Andréa C LeBlanc
Feb 18, 2005·Journal of Neurochemistry·Kenneth L MoyaLuigi Di Giamberardino
Oct 6, 2005·Molecular and Cellular Neurosciences·Rafal ButowtChristopher S von Bartheld
Feb 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cheng Cheng ZhangHarvey F Lodish

❮ Previous
Next ❯

Citations

Jan 1, 2009·International Review of Psychiatry·Paolo BrambillaMichele Tansella
Oct 4, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A Sicras-MainarM Blanca-Tamayo
Mar 29, 2011·Behavioural Brain Research·Vinicius M GadottiGerald W Zamponi
Apr 29, 2014·The European Journal of Neuroscience·Daniel RialRui D Prediger
Sep 20, 2011·The American Journal of Pathology·Gary R MartinFrank R Jirik
Dec 5, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Brian DeanJames A Duce
May 5, 2020·The International Journal of Neuropsychopharmacology·Bill QiYannis J Trakadis
Jun 30, 2019·Molecular Psychiatry·Vijayasree V GiridharanTatiana Barichello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here