Expression of chemokines and chemokine receptors in cutaneous CD30+ lymphoproliferative disorders

The British Journal of Dermatology
T YamaguchiM Kikuchi

Abstract

Little is known about the mechanisms involved in skin-specific homing in CD30+ cutaneous lymphoproliferative disorders (CLPD). Chemokine/chemokine receptor interactions have been implicated in the homing of lymphoma cells to various tissue sites. To investigate tissue samples from patients with CD30+ CLPD for the expression of the chemokine receptors CXCR3, CCR4 and CCR3 and their ligands MIG, TARC and RANTES. Tissue samples from patients with primary cutaneous anaplastic large cell lymphoma (PCALCL, n=12) and lymphomatoid papulosis (LyP, n=13) were studied by immunohistochemistry on paraffin-embedded sections. Immunohistochemical analysis was also performed for CD20 (for B cells), CD45RO and CD3 (for T cells), CD30 and ALK-1. A portion of each skin specimen was stored at -80 degrees C and later examined using monoclonal antibodies against CD2, CD3, CD4, CD5, CD8, CD15, CD19, CD20 and CD30. CD30+ atypical lymphoid cells were frequently seen in PCALCL, and to a variable degree in LyP. In both disorders there were scattered CD3+ and CD45RO+ atypical lymphoid cells, but CD2, CD5, CD15, CD19, CD20 and ALK-1 showed negative reactivity. In addition, CD4+, but not CD8+, atypical lymphoid cells were occasionally seen in both disorders....Continue Reading

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Citations

Mar 28, 2012·International Journal of Hematology·Tomomitsu MiyagakiShinichi Sato
Jun 23, 2009·The American Journal of Dermatopathology·Aieska de SouzaIvana N Micallef
Nov 30, 2012·The American Journal of Dermatopathology·Cynthia M Magro, Xuan Wang
Dec 22, 2009·Future Oncology·Mai P HoangM Angelica Selim
Jan 27, 2016·Critical Reviews in Oncology/hematology·Pier Luigi ZinzaniStefano Pileri
Oct 11, 2011·Journal of the American Academy of Dermatology·Aieska de SouzaLawrence E Gibson
Jun 26, 2010·Journal of Dermatological Science·Makoto Sugaya
Jun 10, 2015·Virchows Archiv : an International Journal of Pathology·Francisco GinerAntonio Llombart-Bosch
Sep 4, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Makoto Sugaya
Aug 5, 2014·International Immunology·Osamu Yoshie, Kouji Matsushima
Jun 2, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Makoto Sugaya
Oct 16, 2018·Frontiers in Medicine·Paula T KuoGraham R Leggatt
Dec 29, 2019·Seminars in Diagnostic Pathology·Vasiliki LeventakiMegan S Lim
Jan 6, 2011·Archives of Pathology & Laboratory Medicine·Marsha C KinneyEdward A Medina

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