Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni

European Journal of Immunology
H J HernandezM J Stadecker

Abstract

Previous studies have suggested that granulomatous inflammation in schistosomiasis is mediated by CD4+ T helper lymphocytes sensitized to parasite egg antigens. However, CD8+ T cells have also frequently been associated with the immune response to schistosome eggs. To examine more precisely the role of CD4+ and CD8+ T cells in the pathology of the schistosomal infection, we used mice with targeted mutations in major histocompatibility complex (MHC) class II or class I molecules. These mutations lead, respectively, to the virtual absence of CD4+ and CD8+ T cells. The results clearly show that schistosome-infected MHC class II mutant mice failed to form granulomas around parasite eggs. In contrast, infected MHC class I mutant mice displayed characteristic granulomatous lesions that were comparable to those in wild-type control mice. Moreover, lymphoid cells from MHC class II mutant mice were unable to react to egg antigens with either proliferative or cytokine [interferon-gamma, interleukin (IL)-4, IL-10] responses; nor were they able to present egg antigens to specifically sensitized CD4+ T helper cells from infected syngeneic control mice. By comparison, cells from MHC class I mutant mice exercised all these functions in a mann...Continue Reading

References

Aug 8, 1976·Nature·C K HsuC T Hansen
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A SherA W Cheever
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jan 1, 1986·Annals of the New York Academy of Sciences·D L Boros
Jul 1, 1967·The American Journal of Tropical Medicine and Hygiene·R J StengerE A Johnson
Jan 1, 1984·Hybridoma·G C Koo, J R Peppard
Oct 1, 1995·The Journal of Experimental Medicine·M M EpsteinP Matzinger
Jul 1, 1994·International Immunology·P MombaertsA K Bhan
Jan 1, 1993·Annual Review of Immunology·R N Germain, D H Margulies
Jan 1, 1964·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z A ANDRADE

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Citations

Oct 26, 2012·Seminars in Immunopathology·Bridget M LarkinMiguel J Stadecker
Nov 10, 2012·Seminars in Immunopathology·Keke FairfaxEdward J Pearce
Jan 9, 2004·International Journal for Parasitology·Stephen J DaviesJames H McKerrow
Jun 23, 2005·International Journal for Parasitology·David L WilliamsMiguel J Stadecker
Oct 17, 2006·Parasitology Today·L R BrunetE J Pearce
Sep 15, 2000·Infectious Disease Clinics of North America·I BicaM J Stadecker
Oct 8, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Afaf El-Ansary
Dec 11, 2003·Parasitology International·Hiroko Asahi, Miguel J Stadecker
Dec 24, 2002·Trends in Immunology·Matyas SandorThomas A Wynn
May 10, 2003·Trends in Immunology·William C GauseMiguel J Stadecker
Nov 26, 2009·Infection and Immunity·B ManivannanA C La Flamme
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·Kazuhiro IyonagaEveline E Schneeberger
Oct 15, 2011·PLoS Pathogens·Patrick M SmithMiguel J Stadecker
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L I RutitzkyM J Stadecker
Aug 26, 1998·Memórias do Instituto Oswaldo Cruz·W Jacobs, E Van Marck
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Allen W CheeverZilton A Andrade
Jun 27, 2006·Scandinavian Journal of Infectious Diseases·Barry PayetFrederic Lucht
Jul 24, 2007·Molecular and Biochemical Parasitology·Cynthia L CassDavid L Williams
Mar 23, 2018·Journal of Cellular and Molecular Medicine·Jifeng ZhuChuan Su
Sep 14, 2004·Immunological Reviews·Miguel J StadeckerJing Sun
Sep 13, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Zi-gang ShenJin-tao Li
Jul 11, 2007·European Journal of Immunology·Laura E LaylandClarissa U Prazeres da Costa
Nov 9, 2005·European Journal of Immunology·Laura E LaylandClarissa U Prazeres da Costa

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