Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Yanning CaiPiu Chan

Abstract

There is a growing number of clinical studies that revealed a variety of behavioral and physiological desynchronies in patients with Parkinson's disease (PD). However, these desynchronies have not been defined at the molecular level. Using real-time RT-PCR assay, we analyzed the expression profiles of two principle clock genes, PER1 and BMAL1, in total leukocytes for 12 h during the evening, overnight and morning in subjects with PD and age/sex-matched healthy controls. A difference in the expression pattern of BMAL1 but not PER1 was apparent during the dark span, where the relative abundance of BMAL1 was significantly lower in PD patients versus control subjects at 21:00, 00:00 and 06:00 h. Furthermore, expression levels of BMAL1 in PD patients correlated with their United Parkinson's Disease Rating Scale score at 06:00, 09:00 h, and with Pittsburgh Sleep Quality Index score at 06:00 h. These results suggest that a peripheral molecular clock, as reflected in the dampened expression of the clock genes BMAL1 in total leukocytes, is altered in PD patients. In addition, the relative BMAL1 levels correlate positively with PD severity, which could provide a molecular basis to help monitor disease progression and response to investig...Continue Reading

Associated Clinical Trials

Feb 27, 2020·Blanca Miriam de Guadalupe Torres Mendoza

References

Feb 22, 2001·Annual Review of Physiology·S M Reppert, D R Weaver
Aug 2, 2002·Clinical Neuropharmacology·Bernard Bruguerolle, Nicolas Simon
Dec 24, 2002·BMC Neuroscience·Jonathan P WisorPaul Franken
Jun 11, 2004·Clinical Neuropharmacology·Alessandra MongeGianpietro Nordera
Aug 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kei NagashimaKazuyuki Kanosue
Sep 13, 2005·Parkinsonism & Related Disorders·Yasuhiko BabaTatsuo Yamada
Nov 29, 2005·Brain, Behavior, and Immunity·Alvaro Arjona, Dipak K Sarkar
Sep 19, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alvaro Arjona, Dipak K Sarkar
Feb 6, 2007·Biochemical and Biophysical Research Communications·Hiroyuki FukuyaMitsuhiro Yokoyama
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anne M CurtisGarret A Fitzgerald
Apr 25, 2007·Chronobiology International·Hugues Dardente, Nicolas Cermakian
Oct 31, 2008·PLoS Biology·Guo-Xiang RuanDouglas G McMahon

❮ Previous
Next ❯

Citations

Mar 2, 2010·Journal of Molecular Neuroscience : MN·Lauren A Segall, Shimon Amir
Jun 29, 2012·Neurotoxicity Research·Seithikurippu R Pandi-PerumalDaniel P Cardinali
Dec 4, 2012·Antioxidants & Redox Signaling·Melissa WilkingNihal Ahmad
Nov 20, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G L Willis, S M Armstrong
Nov 12, 2014·Nature Reviews. Neurology·Aleksandar VidenovicSebastiaan Overeem
Jan 8, 2013·Neuromolecular Medicine·Akane HayashiShigehiro Ohdo
Feb 14, 2012·Chronobiology International·Pedro LaxNicolás Cuenca
Mar 17, 2015·Frontiers in Pharmacology·Erik S Musiek
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Karim Fifel
Jan 22, 2017·Protein & Cell·Fang Liu, Hung-Chun Chang
Apr 23, 2013·Journal of Biological Rhythms·Diego de Siqueira FigueredoTiago Gomes de Andrade
Oct 20, 2011·Therapeutic Advances in Neurological Disorders·Venkatramanujam SrinivasanSeithikurippu R Pandi-Perumal
Oct 5, 2017·Human Molecular Genetics·Aarti JagannathRussell G Foster
Mar 2, 2018·Journal of Sleep Research·Susanna MantovaniJohn D O'Sullivan
Jan 1, 2019·Rejuvenation Research·Karolin YanarUfuk Çakatay
Jun 15, 2019·International Journal of Molecular Sciences·Consiglia PacelliNazzareno Capitanio
Oct 4, 2017·Frontiers in Behavioral Neuroscience·Mariam SabbarNouria Lakhdar-Ghazal
Apr 5, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wen-Wen LiuChun-Feng Liu
Nov 2, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Eduardo De Pablo-FernándezThomas T Warner
Dec 21, 2016·Neuroscience Bulletin·Siyue LiChun-Feng Liu
Aug 8, 2019·Cellular and Molecular Neurobiology·Omid Reza TamtajiZatollah Asemi
Sep 29, 2020·Journal of Parkinson's Disease·Beatrix FeiglAndrew J Zele
Jun 22, 2013·Current Opinion in Neurology·Maria P GiannoccaroGiuseppe Plazzi
Feb 28, 2014·Journal of Pharmacological Sciences·Yu Tahara, Shigenobu Shibata
Jun 15, 2017·Frontiers in Aging Neuroscience·Suzanne Hood, Shimon Amir
Sep 12, 2018·Acta Neuropathologica Communications·Isabel Ortuño-LizaránNicolás Cuenca
Jun 7, 2018·International Journal of Epidemiology·Yue LengKristine Yaffe
Dec 20, 2018·International Journal of Molecular Sciences·Federica De LazzariFederica Sandrelli
Jan 11, 2012·International Journal of Immunopathology and Pharmacology·G MazzoccoliY Cai
May 20, 2017·Frontiers in Neurology·Chiara La MorgiaValerio Carelli
Nov 26, 2016·Science·Erik S Musiek, David M Holtzman
Aug 5, 2017·Frontiers in Molecular Neuroscience·Ernesto Miranda-MoralesOscar Arias-Carrión
Dec 14, 2019·Journal of Neuroscience Research·Yu Chen Chang, Jin Young Kim
Aug 28, 2020·Frontiers in Neuroscience·Arastu SharmaSung Ung Kang
Apr 20, 2017·Frontiers in Cellular Neuroscience·Kirill S KorshunovPaul Q Trombley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.