Expression of co-factors (SMRT and Trip-1) for retinoic acid receptors in human neuroectodermal cell lines

Biochemical and Biophysical Research Communications
S BernardiniG Federici

Abstract

Retinoic acid (RA) induces growth inhibition, differentiation or cell death in many human neuroblastoma cell lines. Recently, the transactivation activity of nuclear retinoids receptors has been shown to be modulated through physical association with other proteins that act as co-activators or as co-repressors. We investigated the expression of the co-repressor (SMRT) and co-activator (Trip 1) for retinoid and thyroid-hormone receptors in several neuroectodermal tumour cell lines, and its modulation by all-trans-retinoic acid, as well as by synthetic agonists, for RAR alpha, RAR beta, RAR gamma and RXR. We demonstrate that (i) SMRT and Trip-1 mRNAs are expressed in many human neuroblastoma and melanoma cell lines in basal conditions, (ii) SMRT mRNA expression in human neuroblastoma cell line SK-N-BE(2) increases after 48 hours of incubation with 1 microM RA and RARs specific agonists, (iii) Trip-1 mRNA in the same cell line does not change during incubation with RA or selective synthetic agonists for RARs and RXR.

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Citations

Dec 3, 2014·Biochimica Et Biophysica Acta·John W B Hershey
May 23, 2002·BMC Pharmacology·Céline BrandPhilippe Lefebvre
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Muhammad Umar AliCao Jiang
Jul 24, 2001·Medical and Pediatric Oncology·P E LovatC P Redfern
Sep 26, 2008·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Michael Constantino, Lotte Smith-Hansen
Jan 20, 2018·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Juan Martin Gomez PenedoLotte Smith-Hansen
Dec 20, 2018·Epigenomics·Katerina GrafanakiConstantinos Stathopoulos

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