Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yan ZhangHongming Chen

Abstract

Esophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors. Immunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues. In addition to the relationships between the expression of Cofilin-1 and transgelin, the clinicopathologic features of ESCC were also discussed. The correlation between Cofilin-1 and transgelin protein expression in ESCC was analyzed. (1) The positive expression rates of Cofilin-1 and transgelin were 60.3% (41/68) and 54.4% (37/68) in esophageal carcinoma tissue, respectively. The positive expression rates of Cofilin-1 and transgelin in normal esophageal tissue were 27.1% (13/48) and 29.1% (14/48), respectively. The differences were statistically significant (P<0.05). (2) The positive expression rate of Cofilin-1 did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, or infiltration depth; but did have a statistica...Continue Reading

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Citations

Nov 20, 2019·Medicinal Research Reviews·Tuhina KhanGiuseppe Campiani
May 21, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lei WangIlyar Sheyhidin
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Jingwen LiuYan Wang

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Methods Mentioned

BETA
electrophoresis
surgical resection

Software Mentioned

ImageMASTER
SPSS17

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