PMID: 7544131Feb 1, 1995Paper

Expression of complement regulatory proteins on human eggs and preimplantation embryos

American Journal of Reproductive Immunology : AJRI
P FenichelB L Hsi

Abstract

To investigate the relation between the complement system and reproduction, expression of complement regulatory proteins (C3b receptors and inhibitor of the membrane attack complex) were screened on unfixed human eggs and preimplantation embryos. Unfixed unfertilized oocytes and preimplantation embryos obtained from an in vitro fertilization program were stained by indirect immunofluorescence using monoclonal antibodies raised against membrane cofactor protein, (MCP or CD46), decay accelerating factor (DAF or CD55), protectin (CD59), human C3b/C4b receptor (CR1 or CD35), and major histocompatibility complex class I antigen (MHC class I). CD55 and CD59 were both expressed by the plasma membrane of unfertilized oocytes and pre-implantation embryos. CD46 was not expressed by unfertilized oocytes but appeared at the 6-to-8 cell stage embryo when human gene expression first occurs. CD35 and MHC class I antigens were not expressed at all on oocytes and preimplantation embryos. Selective expression of complement regulatory proteins (DAF and protectin) associated with the lack of MHC class I antigens may represent an immune protective mechanism by which human oocytes and preimplantation embryos escape complement-mediated damage during ...Continue Reading

References

Mar 1, 1978·Developmental Biology·A C Menge, C H Fleming
Nov 1, 1977·The Journal of Experimental Zoology·M G O'Rand
Apr 1, 1992·American Journal of Reproductive Immunology : AJRI·O A VanderpuyeJ A McIntyre
Oct 1, 1992·Fertility and Sterility·J TesarikA Carreras
Apr 1, 1991·Journal of Reproductive Immunology·B L HsiJ P Atkinson
May 1, 1991·Fertility and Sterility·P FénichelB L Hsi
Oct 1, 1990·Molecular Reproduction and Development·P FénichelB L Hsi
Nov 1, 1990·Clinical and Experimental Immunology·R PerriconeL Fontana
Apr 13, 1990·Science·S KovatsR DeMars
Sep 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·B L HsiC Grivaux
May 1, 1989·Fertility and Sterility·P FénichelM Harter
Apr 1, 1989·Molecular Endocrinology·M A ShupnikW W Chin
Sep 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·A C Menge, R K Naz
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·N K SpurrW F Bodmer
Jun 1, 1983·American Journal of Reproductive Immunology : AJRI·C W Redman
Jun 1, 1984·American Journal of Reproductive Immunology : AJRI·G N ClarkeM N Cauchi
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D J AndersonR M Jack
Jan 1, 1987·Immunology Today·J P Atkinson, T Farries

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Citations

Jun 9, 1998·Journal of Reproductive Immunology·R BronsonB Ghebrehiwet
Sep 8, 1998·Journal of Reproductive Immunology·H Hutter, G Dohr
Sep 21, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R J LlanosD C Miceli
Sep 1, 1996·American Journal of Reproductive Immunology : AJRI·B O NilssonP Sundström
Jul 19, 2005·Molecular Immunology·Claire L HarrisB Paul Morgan
Feb 9, 1999·Prenatal Diagnosis·E Pergament, M Fiddler
Oct 18, 2019·Frontiers in Immunology·Martin P ReichhardtTimo Tuuri
Feb 18, 2020·Theriogenology·Sabine Schäfer-SomiSelim Aslan

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