Expression of connective tissue growth factor in male breast cancer: clinicopathologic correlations and prognostic value

PloS One
Miangela M LacleTri Q Nguyen

Abstract

Connective tissue growth factor (CTGF/CCN2) is a member of the CCN family of secreted proteins that are believed to play an important role in the development of neoplasia. In particular, CTGF has been reported to play an important role in mammary tumorigenesis and to have prognostic value in female breast cancer (FBC). The aim of the present study was to investigate clinicopathologic correlations and prognostic value of CTGF in male breast cancer (MBC) and to compare these findings with FBC. For this, we studied CTGF protein expression by immunohistochemistry in 109 MBC cases and 75 FBC cases. In MBC, stromal CTGF expression was seen in the majority of the cases 78% (85/109) with high expression in 31/109 cases (28.4%), but expression in tumor cells was only seen in 9.2% (10/109) of cases. High stromal CTGF expression correlated with high grade and high proliferation index (>15%) assessed by MIB-1 immunohistochemical staining. CTGF expression in tumor epithelial cells did not correlate with any of the clinicopathologic features. In FBC, stromal CTGF expression positively correlated with mitotic count and tumor CTGF expression was associated with triple negative status of the tumor (p = 0.002). Neither stromal nor tumor epitheli...Continue Reading

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Citations

Oct 17, 2019·Genes·Dhananjay HuilgolSonali Bhattacharjee
Aug 16, 2016·Journal of Cell Communication and Signaling·Herman Yeger, Bernard Perbal
Feb 20, 2021·Dermatologic Therapy·Yomna Mazid El-Hamd NeinaaNashwa Naeem Elfar
Aug 31, 2021·Virchows Archiv : an International Journal of Pathology·Stephen FoxAbeer M Shaaban

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