Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy

The Journal of Pathology
Dr ThalCs Clemen

Abstract

Coronin-3 (coronin-1C), a homotrimeric F-actin binding protein, has been shown to be important for cell migration and brain morphogenesis. Here, we present for the first time a detailed analysis of the expression pattern of coronin-3 in human brain tumours and demonstrate that coronin-3 expression correlates with malignant phenotype in diffuse gliomas. In general, the expression of coronin-3 varies in different brain tumour entities. However, in diffuse gliomas, the number of coronin-3 expressing tumour cells correlates with the degree of malignancy. High-grade gliomas, such as anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and glioblastomas, show high numbers of tumour cells positive for coronin-3, while diffuse low-grade gliomas, such as diffuse astrocytomas, oligodendrogliomas and oligoastrocytomas, exhibit low numbers of coronin-3-positive tumour cells. In order to explore and verify a contribution of coronin-3 to the malignant phenotype of diffuse gliomas, we employed an efficient shRNA-mediated coronin-3 knockdown in U373 and A172 human glioblastoma cells. Coronin-3 knockdown glioblastoma cells exhibited reduced levels of cell proliferation, cell motility and invasion into extracellul...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1995·The Journal of Cell Biology·C C Cunningham
Aug 26, 1999·Trends in Cell Biology·E L de Hostos
May 31, 2001·Science·D PantaloniM F Carlier
Oct 9, 2001·Journal of Neuropathology and Experimental Neurology·I BlümckeG Reifenberger
May 9, 2002·Journal of Neuro-oncology·Devin K Binder, Mitchel S Berger
Dec 25, 2002·The Journal of Cell Biology·Christine L HumphriesBruce L Goode
Apr 2, 2003·Cell Biology Education·Bruce Alberts, UNKNOWN National Academies
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GieseM Westphal
Jul 2, 2003·Nature Reviews. Cancer·Jasti S Rao
Mar 19, 2005·Science·Michael Glotzer
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Florence LefrancRobert Kiss
Apr 9, 2005·The European Journal of Neuroscience·Andreas HasseChristoph S Clemen
May 14, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Vasily Rybakin, Christoph S Clemen
May 17, 2005·Experimental Cell Research·Anna-Eleonor OsiakStefan Linder
Jun 30, 2006·Trends in Cell Biology·Andrea C Uetrecht, James E Bear
Jul 11, 2006·Clinical & Experimental Metastasis·Alissa M Weaver
Feb 6, 2007·Experimental Cell Research·André RosentreterChristoph S Clemen

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Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edward L HuttlinMichael R Sussman
Feb 16, 2013·Neuro-oncology·Anja ZiemannChristoph S Clemen
Mar 1, 2012·The Biochemical Journal·Keefe T ChanJames E Bear
Dec 30, 2014·Journal of Proteome Research·Athanasios K AnagnostopoulosGeorge Th Tsangaris
Feb 23, 2012·Scientific Reports·Charles-Peter XavierChristoph S Clemen
Oct 9, 2019·Molecular and Cellular Biochemistry·Xin Jun WangPei Ming Bai
Dec 8, 2017·Physiological Reviews·Nicolas Molinie, Alexis Gautreau
May 25, 2021·Frontiers in Cell and Developmental Biology·Xinjun WangGuangcheng Luo
Oct 12, 2010·Journal of Proteome Research·Robert KlopfleischAchim D Gruber
Aug 5, 2009·Journal of Molecular Biology·Charles-Peter XavierChristoph S Clemen

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