Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jennifer LaBergeMargaret A Vizzard

Abstract

Corticotropin-releasing factor (CRF) is a prominent neuropeptide involved in micturition reflexes, and different roles in these reflexes have been suggested. These studies examined the expression of CRF in the urinary bladder and lumbosacral sacral parasympathetic nucleus (SPN) in response to cyclophosphamide (CYP)-induced cystitis (4 h, 48 h, or chronic) in rats. The expression of CRF receptors, CRF(1) and CRF(2), was examined in urinary bladder from control and CYP-treated rats. Urinary bladder and lumbosacral spinal cord were harvested from rats killed by isoflurane (4%) and thoracotomy. CRF protein expression in whole urinary bladders significantly (P < or = 0.01) increased with 48 h or chronic CYP treatment. CRF immunoreactivity (IR) was increased significantly (P < or = 0.01) in the urothelium and SPN after CYP treatment. CRF IR nerve fibers increased in density in the suburothelial plexus and detrusor smooth muscle whole mounts with CYP-induced cystitis. CRF(2) receptor transcript was expressed in the urothelium or detrusor smooth muscle, and CRF(2) receptor expression increased in whole bladder with CYP-treatment, whereas no CRF(1) receptor transcript was expressed in either urothelium or detrusor. Immunohistochemical s...Continue Reading

References

Aug 31, 1979·Brain Research·A D LoewyR P Baker
May 15, 1992·Journal of the Autonomic Nervous System·C A MaggiS Giuliani
Nov 1, 1991·The Journal of Clinical Investigation·W D SteersJ B Tuttle
May 1, 1989·The Journal of Urology·L A Levine, J P Richie
Mar 1, 1989·British Journal of Urology·C R AnderströmS L Johansson
Oct 1, 1988·The Journal of Urology·W D Steers, W C De Groat
Dec 1, 1973·British Journal of Urology·N A Watson, R G Notley
Dec 1, 1982·The American Journal of Anatomy·I MerchenthalerA V Schally
Oct 1, 1994·Journal of the Autonomic Nervous System·J B TuttleE Nataluk
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M A Vizzard
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L A BirderM J Caterina
Nov 7, 2001·The Journal of Urology·A Driscoll, J M Teichman
Apr 12, 2002·Physiological Genomics·Susan E Malley, Margaret A Vizzard
Jun 12, 2002·The American Journal of Pathology·Marcia R SabanRicardo Saban
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V Y HuM A Vizzard
Dec 23, 2003·The European Journal of Neuroscience·Marie-Laure Rouzade-DominguezRita J Valentino
Mar 12, 2004·Urology·Michael B Chancellor, Naoki Yoshimura
Nov 13, 2004·The Journal of Urology·Adam P Klausner, William D Steers
Jan 8, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christophe PorcherBruno Bonaz
Feb 16, 2005·The Journal of Urology·Vivian Y HuMargaret A Vizzard
Aug 12, 2005·American Journal of Physiology. Renal Physiology·Lori A Birder

❮ Previous
Next ❯

Citations

Jun 19, 2008·Journal of Molecular Neuroscience : MN·Simon StudenyMargaret A Vizzard
Dec 8, 2010·Nature Reviews. Urology·Rita J ValentinoStephen A Zderic
Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan K WoodRita J Valentino
Feb 19, 2010·American Journal of Physiology. Renal Physiology·Kimberly CorrowMargaret A Vizzard
May 16, 2014·The Journal of Endocrinology·Ann T Hanna-MitchellLori A Birder
Mar 2, 2016·Nature Reviews. Urology·Liana MerrillMargaret A Vizzard
Aug 12, 2009·Autonomic Neuroscience : Basic & Clinical·Lori A Birder
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Dec 22, 2009·Neurourology and Urodynamics·Lori A BirderAnn T Hanna-Mitchell
Dec 22, 2009·Neurourology and Urodynamics·L BirderM Drake
Jul 4, 2008·Autonomic Neuroscience : Basic & Clinical·Jennifer LaBergeMargaret A Vizzard
Oct 25, 2016·Experimental Neurology·Beatrice GirardMargaret A Vizzard
Jan 15, 2008·The Journal of Comparative Neurology·Mary Beth KlingerMargaret A Vizzard
Dec 20, 2017·Frontiers in Systems Neuroscience·Beatrice M GirardMargaret A Vizzard
Dec 30, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M MillionY Taché
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly A Corrow, Margaret A Vizzard
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary Beth KlingerMargaret A Vizzard
Apr 17, 2013·Physiological Reviews·Lori Birder, Karl-Erik Andersson
Feb 2, 2018·International Neurourology Journal·Lori Birder, Karl-Erik Andersson
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan K WoodRita J Valentino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Darcie A KiddooDimitri E Grigoriadis
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Kimberly Corrow, Margaret A Vizzard
Autonomic Neuroscience : Basic & Clinical
Jennifer LaBergeMargaret A Vizzard
© 2022 Meta ULC. All rights reserved